Transcription Factor
| Accessions: | Q9UKW6 (JASPAR 2024) |
| Names: | E74-like factor 5, ELF5_HUMAN, Epithelium-restricted ESE-1-related Ets factor, Epithelium-specific Ets transcription factor 2, ESE-2, ETS-related transcription factor Elf-5 |
| Organisms: | Homo sapiens, Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9UKW6 |
| Length: | 265 |
| Pfam Domains: | 47-128 Sterile alpha motif (SAM)/Pointed domain 174-255 Ets-domain |
| Sequence: (in bold interface residues) | 1 MPSLPHSHRVMLDSVTHSTFLPNASFCDPLMSWTDLFSNEEYYPAFEHQTACDSYWTSVH 60 61 PEYWTKRHVWEWLQFCCDQYKLDTNCISFCNFNISGLQLCSMTQEEFVEAAGLCGEYLYF 120 121 ILQNIRTQGYSFFNDAEESKATIKDYADSNCLKTSGIKSQDCHSHSRTSLQSSHLWEFVR 180 181 DLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTG 240 241 ILERVDRRLVYKFGKNAHGWQEDKL |
| Interface Residues: | 227, 228, 230, 231, 232, 234, 235, 248 |
| 3D-footprint Homologues: | 7jsa_J, 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B |
| Binding Motifs: | MA0136.1 waywTCCkk MA0136.2 acsmGGAAGtr |
| Binding Sites: | MA0136.1.1 MA0136.1.10 MA0136.1.11 MA0136.1.12 MA0136.1.13 MA0136.1.14 MA0136.1.15 MA0136.1.16 MA0136.1.17 MA0136.1.18 MA0136.1.19 MA0136.1.2 MA0136.1.20 MA0136.1.3 MA0136.1.4 MA0136.1.5 MA0136.1.6 MA0136.1.7 MA0136.1.8 MA0136.1.9 |
| Publications: | Choi Y.S, Sinha S. Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2. The Biochemical journal 398:497-507 (2006). [Pubmed] Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed] |
| Related annotations: | PaperBLAST |
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