Transcription Factor

Accessions: VAX2 (HT-SELEX2 May2017), Q9UIW0 (JASPAR 2024)
Names: ENSG00000116035, VAX2, VAX2_HUMAN
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3
Length: 290
Pfam Domains: 103-159 Homeobox domain
Sequence:
(in bold interface residues)
1 MGDGGAERDRGPARRAESGGGGGRCGDRSGAGDLRADGGGHSPTEVAGTSASSPAGSRES 60
61 GADSDGQPGPGEADHCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLEME 120
121 FQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQSRDLEKRASSSASEAFATS 180
181 NILRLLEQGRLLSVPRAPSLLALTPSLPGLPASHRGTSLGDPRNSSPRLNPLSSASASPP 240
241 LPPPLPAVCFSSAPLLDLPAGYELGSSAFEPYSWLERKVGSASSCKKANT
Interface Residues: 103, 104, 105, 106, 144, 145, 147, 148, 151, 152, 155, 156, 159, 168, 171
3D-footprint Homologues: 5zfz_A, 3d1n_M, 1fjl_B, 6a8r_A, 2h1k_B, 1puf_A, 3cmy_A, 6m3d_C, 1nk2_P, 1zq3_P, 3lnq_A, 2lkx_A, 1jgg_B, 2ld5_A, 7q3o_C, 6es3_K, 2hdd_A, 3rkq_B, 2r5y_A, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 7psx_B, 1b72_A, 5hod_A, 3l1p_A, 1ig7_A, 3a01_E, 5jlw_D, 4xrs_G, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 1le8_A, 1mnm_C, 1puf_B, 1k61_B, 8g87_X, 1o4x_A, 4qtr_D, 1le8_B, 1du0_A
Binding Motifs: MA0723.1 yTAATkAc
VAX2_2 sYAATTAs
VAX2_methyl_1 sYAATTAs
MA0723.2 syaATTAr
MA0723.3 yaATTA
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]
Related annotations: PaperBLAST

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