Transcription Factor
| Accessions: | TF7L2_MOUSE (HOCOMOCO 10), Q924A0 (JASPAR 2024) |
| Names: | HMG box transcription factor 4, mTCF-4, T-cell factor 4, T-cell-specific transcription factor 4, TCF-4, TF7L2_MOUSE, Transcription factor 7-like 2 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 459 |
| Pfam Domains: | 1-236 N-terminal CTNNB1 binding 327-394 HMG (high mobility group) box 328-385 Domain of unknown function (DUF1898) |
| Sequence: (in bold interface residues) | 1 MPQLNGGGGDDLGANDELISFKDEGEQEEKNSENSSAERDLADVKSSLVNESETNQDSSS 60 61 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS 120 121 LSPTARTYLQMKWPLLDVQAGSLQSRQTLKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL 180 181 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQ 240 241 QGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES 300 301 SQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQI 360 361 LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSE 420 421 CFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCSL |
| Interface Residues: | 329, 332, 334, 335, 338, 342, 353, 354, 355, 358, 396, 398, 400, 403, 405, 406, 407, 410, 442 |
| 3D-footprint Homologues: | 1j5n_A, 3f27_D, 6jrp_D, 1o4x_B, 3u2b_C, 2gzk_A, 4s2q_D, 7m5w_A, 2lef_A, 4y60_C, 1hry_A, 7dta_A |
| Binding Motifs: | PB0188.1 sdrsWTCAATCrstww TF7L2_MOUSE.H10MO.A|M01387 bcCTTTGAwsty PB0084.1 ddkycCTTTGATstwta |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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