Transcription Factor
| Accessions: | T000176_1.02 (CISBP 1.02), UP00452A (UniPROBE 20160601), P14164 (JASPAR 2024) |
| Names: | ABF1, T000176_1.02;, ARS-Binding Factor 1, BAF1, OBF1, REB2, SBF1, ABF1_YEAST, Bidirectionally acting factor 1, DNA replication enhancer-binding protein OBF1, SFB-B |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | ARS-Binding Factor 1: DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair |
| Notes: | experiment type:PBM, family:ABF1 |
| Length: | 731 |
| Pfam Domains: | 8-134 BAF1 / ABF1 chromatin reorganising factor 321-507 BAF1 / ABF1 chromatin reorganising factor |
| Sequence: (in bold interface residues) | 1 MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNK 60 61 HFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDN 120 121 NNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQ 180 181 QGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVND 240 241 EDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGI 300 301 SSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKIL 360 361 QNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIAR 420 421 RITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAG 480 481 TSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQ 540 541 ITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGH 600 601 NNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKE 660 661 VENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLS 720 721 DENIQPELRGQ |
| Interface Residues: | 50, 51, 54, 55, 58, 309, 579, 580, 583, 587, 610 |
| 3D-footprint Homologues: | 1w0t_A, 3m4a_A, 5g5t_A |
| Binding Motifs: | M0001_1.02 TTATCACT UP00452A_1 tcgTCaCgCyGyACGAarwrAt MA0265.1 yCGTakrwartGAyaw MA0265.2 wtttCGTatawARTGAyatw MA0265.3 tCGTatawARTGAy |
| Binding Sites: | AATATCAC AATGATAT AGATCACT AGTGACAA AGTGACAT AGTGATAA AGTGATAT ATAGTGAT ATATCACC ATGTACGA ATGTCACC ATGTCACG ATTATCAC CCGTACAA CCGTACGA CGTACGAA GAGTGACA GTGACATA TAGTGATA TCGTACGA MA0265.2.1 MA0265.2.10 / MA0265.2.12 MA0265.2.11 / MA0265.2.13 MA0265.2.12 / MA0265.2.14 MA0265.2.13 / MA0265.2.15 MA0265.2.14 / MA0265.2.18 MA0265.2.15 / MA0265.2.19 MA0265.2.16 / MA0265.2.20 MA0265.2.17 MA0265.2.18 MA0265.2.19 MA0265.2.2 / MA0265.2.3 MA0265.2.20 MA0265.2.3 / MA0265.2.5 MA0265.2.4 MA0265.2.5 / MA0265.2.6 MA0265.2.6 / MA0265.2.8 MA0265.2.7 / MA0265.2.9 MA0265.2.10 / MA0265.2.8 MA0265.2.11 / MA0265.2.9 MA0265.2.16 MA0265.2.17 MA0265.2.2 MA0265.2.4 MA0265.2.7 MA0265.3.1 MA0265.3.10 MA0265.3.11 MA0265.3.12 MA0265.3.13 MA0265.3.14 MA0265.3.15 MA0265.3.16 MA0265.3.17 MA0265.3.18 MA0265.3.19 MA0265.3.2 MA0265.3.20 MA0265.3.3 MA0265.3.4 MA0265.3.5 MA0265.3.6 MA0265.3.7 MA0265.3.8 MA0265.3.9 |
| Publications: | Gordân R, Murphy KF, McCord RP, Zhu C, Vedenko A, Bulyk ML. Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol : (2011). [Pubmed] Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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