Transcription Factor
| Accessions: | 1apl_D (3D-footprint 20231221), 1k61_D (3D-footprint 20231221) |
| Names: | Alpha-2 repressor, MAT-ALPHA2 HOMEODOMAIN, MATalpha2 protein, Mating-type protein ALPHA2, MTAL2_YEAST, Mating-type protein alpha-2 |
| Organisms: | Saccharomyces cerevisiae, Saccharomyces cerevisiae (strain ATCC 204508 / S288c) |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P0CY08 |
| Length: | 58 |
| Pfam Domains: | 4-57 Homeobox domain 16-54 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 RGHRFTKENVRILESWFAKNIENPYLDTKGLENLMKNTSLSRIQIKNWVSNRRRKEKT |
| Interface Residues: | 1, 3, 4, 43, 44, 46, 47, 50, 51, 54, 55 |
| 3D-footprint Homologues: | 1mnm_C, 1k61_B, 1le8_B, 4j19_B, 2ld5_A, 5jlw_D, 7q3o_C, 1e3o_C, 7xrc_C, 1ig7_A, 2xsd_C, 1du0_A, 6es3_K, 3rkq_B, 5flv_I, 3a01_E, 1puf_B, 6fqp_B, 3cmy_A, 1zq3_P, 6fqq_E, 4xrm_B, 2lkx_A, 1b72_A, 8g87_X, 5zjt_E, 3d1n_M, 2hdd_A, 1jgg_B, 7psx_B, 4xrs_G, 1nk2_P, 2hos_A |
| Binding Motifs: | 1apl_CD TTGTAnTTnATnTACA 1apl_D TGTanTt 1k61_ABCD GCTTGTAAAnGAATTACA |
| Binding Sites: | 1apl_A / 1k61_E 1apl_B / 1k61_F |
| Publications: | Wolberger C., Vershon A. K., Liu B., Johnson A. D., Pabo C. O. Crystal structure of a MATalpha2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions. Cell 67:517-528 (1991). [Pubmed] Aishima J, Gitti R.K, Noah J.E, Gan H.H, Schlick T, Wolberger C. A Hoogsteen base pair embedded in undistorted B-DNA. Nucleic acids research 30:5244-52 (2002). [Pubmed] |
| Related annotations: | PaperBLAST |
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