Transcription Factor

						

			
Accessions: Eip74EF (DrosophilaTF 1.1), P20105 (JASPAR 2024)

			
Names: E74EA_DROME, Ecdysone-induced protein 74EF isoform A, ETS-related protein E74A
Organisms: Drosophila melanogaster
Libraries: DrosophilaTF 1.1 1, JASPAR 2024 2
1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P20105
Length: 829
Pfam Domains:   733-816 Ets-domain
Sequence: 
(in bold interface residues)		   1 MPFIDDALLWCPDNDGRLVGGLDLGTCIADDSTANGTENLNPSIQSAGNPNNPQQSVGGE   60
  61 ILGSVESAGNELNGAAARNVNVVVEPLCGGDSSDELFRSFSESNFEIESLLSDLATVEVK  120
 121 VENEENNNNVITDDDFASVAAAVVANDDLLAKENAQLSAQGLVDSVAASLADSGDAGGQQ  180
 181 ALLAFGSSSSAASAIAAAAAALCGDLINNNNNNSNSNNNSNGNGNHGGGGGGASSGGGVA  240
 241 GDCATKLEYALMGGQPLAEEPRFVTSAAANPLLVEKLMSKCLNIEKRMDKLSDTEIPIVK  300
 301 QSTSPAPQQQLQQQHHLQQQQQQQPHNGSTFAGATALLHIKTEQNTLLTPLQLQQQQQQQ  360
 361 QGLHGAAGNGGSSNGNNAHQQQQPLAIPQRPLLHNLLSGGAIHNPHHRNYTTATTGSFPP  420
 421 SPADSGVSDVDSSSSGGQPCADELKARLGMPPATSASAAAAAAAAAAAAAHLHTGTFLHP  480
 481 NLYQNNAANSLRNIWNRSVGVPDNYYGSSGAGSGGTQPGGPGNPQTPGYLTTSYFNAPTA  540
 541 ATAAASQRGTTINGYHSLHQQQQQQQQSQQSQQQQQLAHQQLSHQQQQALHQQLSHQQQQ  600
 601 QQQQQQQHPHSQLNGPHPHSHPHSHPHSHPHAGQHTHSTIAAAAAAAAASVVSSSSSAVA  660
 661 AAAMLSASAAAAATAAAAAGGSQSVIQPATSSVSYDLSYMLELGGFQQRKAKKPRKPKLE  720
 721 MGVKRRSREGSTTYLWEFLLKLLQDREYCPRFIKWTNREKGVFKLVDSKAVSRLWGMHKN  780
 781 KPDMNYETMGRALRYYYQRGILAKVDGQRLVYQFVDVPKDIIEIDCNGV
Interface Residues: 787, 788, 790, 791, 792, 794, 795, 809
3D-footprint Homologues: 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 1bc8_C, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A
Binding Motifs: Eip74EF mgAAyCMGGAArTgrks
MA0026.1 CMGGAAr
Binding Sites: Eip74EF_1
Eip74EF_2
Eip74EF_3
Eip74EF_4
Eip74EF_5
Eip74EF_6
Eip74EF_7
Eip74EF_8
Eip74EF_9
Eip74EF_11
Eip74EF_12
Eip74EF_13
Eip74EF_15
Eip74EF_16
Eip74EF_10
Eip74EF_14
Eip74EF_17
MA0026.1.1
MA0026.1.10
MA0026.1.11
MA0026.1.12
MA0026.1.13
MA0026.1.14
MA0026.1.15
MA0026.1.16
MA0026.1.17
MA0026.1.2
MA0026.1.3
MA0026.1.4
MA0026.1.5
MA0026.1.6
MA0026.1.7
MA0026.1.8
MA0026.1.9
			
Publications: Urness L. D., Thummel C. S. Molecular interactions within the ecdysone regulatory hierarchy: DNA binding properties of the Drosophila ecdysone-inducible E74A protein. Cell 63:47-61 (1990). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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