Transcription Factor
| Accessions: | Q6ISB3 (JASPAR 2024) |
| Names: | Brother of mammalian grainyhead, Grainyhead-like protein 2 homolog, GRHL2_HUMAN, Transcription factor CP2-like 3 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q6ISB3 |
| Length: | 625 |
| Pfam Domains: | 220-438 CP2 transcription factor |
| Sequence: (in bold interface residues) | 1 MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDS 60 61 AAALGLLYDYYKVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTV 120 121 PVNLSLNQDHLENSKREQYSISFPESSAIIPVSGITVVKAEDFTPVFMAPPVHYPRGDGE 180 181 EQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMY 240 241 DQTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVV 300 301 MVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWD 360 361 VNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKG 420 421 AERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVL 480 481 FIPDVHFANLQRTGQVYYNTDDEREGGSVLVKRMFRPMEEEFGPVPSKQMKEEGTKRVLL 540 541 YVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEH 600 601 YSNEDTFILNMESMVEGFKVTLMEI |
| Interface Residues: | 73, 418, 423, 426 |
| 3D-footprint Homologues: | 6mrj_D, 5mpf_B |
| Binding Motifs: | MA1105.1 ghmaAACCAGTTytd MA1105.2 arAACAGGTTtk MA1105.3 AACAGGTT |
| Binding Sites: | MA1105.1.1 MA1105.1.10 MA1105.1.11 MA1105.1.12 MA1105.1.13 MA1105.1.14 MA1105.1.15 MA1105.1.16 MA1105.1.17 MA1105.1.18 MA1105.1.19 MA1105.1.2 MA1105.1.20 MA1105.1.3 MA1105.1.4 MA1105.1.5 MA1105.1.6 MA1105.1.7 MA1105.1.8 MA1105.1.9 MA1105.2.1 MA1105.2.10 MA1105.2.11 / MA1105.2.7 MA1105.2.12 / MA1105.2.8 MA1105.2.13 / MA1105.2.9 MA1105.2.10 / MA1105.2.14 MA1105.2.11 / MA1105.2.15 MA1105.2.12 / MA1105.2.16 MA1105.2.17 MA1105.2.14 / MA1105.2.18 MA1105.2.15 / MA1105.2.19 MA1105.2.1 / MA1105.2.2 MA1105.2.16 / MA1105.2.20 MA1105.2.2 / MA1105.2.3 MA1105.2.3 / MA1105.2.4 MA1105.2.4 / MA1105.2.5 MA1105.2.6 MA1105.2.7 MA1105.2.5 / MA1105.2.8 MA1105.2.6 / MA1105.2.9 MA1105.2.13 MA1105.2.17 MA1105.2.18 MA1105.2.19 MA1105.2.20 MA1105.3.1 / MA1105.3.16 / MA1105.3.4 MA1105.3.10 / MA1105.3.20 MA1105.3.11 MA1105.3.12 / MA1105.3.2 / MA1105.3.7 MA1105.3.13 / MA1105.3.19 MA1105.3.14 MA1105.3.15 / MA1105.3.8 MA1105.3.17 MA1105.3.18 MA1105.3.3 MA1105.3.5 / MA1105.3.6 MA1105.3.9 |
| Publications: | Werth M, Walentin K, Aue A, Schönheit J, Wuebken A, Pode-Shakked N, Vilianovitch L, Erdmann B, Dekel B, Bader M, Barasch J, Rosenbauer F, Luft FC, Schmidt-Ott KM. The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex. Development 137:3835-45 (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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