Transcription Factor
Accessions: | P43687 (JASPAR 2024) |
Names: | HMX2_MOUSE, Homeobox protein HMX2, Homeobox protein Nkx-5.2 |
Organisms: | Mus musculus |
Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | P43687 |
Length: | 273 |
Pfam Domains: | 150-206 Homeobox domain |
Sequence: (in bold interface residues) | 1 MGSKEDVGKGCPAAGGVSSFTIQSILGGGPSEAPREPAGWPARKRSLSVSSEEEEPEEGW 60 61 KAPACFCPDPHGPKEPSPKHHTPIPFPCLGTPKGSGGAGPAASERTPFLSPSHPDFKEEK 120 121 ERLLPAGSPSPGPERPRDGGAERQTGAAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERA 180 181 CLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVGMPLVFRDSSLLRV 240 241 PVPRSLAFPAPLYYPSSNLSALPLYNLYNKLDY |
Interface Residues: | 132, 133, 136, 149, 150, 151, 152, 153, 191, 192, 194, 195, 198, 199, 202, 203, 206 |
3D-footprint Homologues: | 5zfz_A, 4j19_B, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 1fjl_B, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 2ld5_A, 6es3_K, 7q3o_C, 5zjt_E, 3a01_E, 5hod_A, 2hdd_A, 7psx_B, 5jlw_D, 3rkq_B, 2r5y_A, 1au7_A, 4xrs_G, 2hos_A, 4cyc_A, 1b72_A, 5flv_I, 3l1p_A, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 1o4x_A, 1le8_B, 6fqq_E, 1du0_A, 8g87_X, 4qtr_D, 1mnm_C, 1puf_B, 1k61_B, 6fqp_B |
Binding Motifs: | MA0897.1 / PH0042.1 acaAgCAATTAAwgvrT MA0897.2 aAgCAATTAAwgvrT |
Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.