Transcription Factor

Accessions: P43687 (JASPAR 2024)
Names: HMX2_MOUSE, Homeobox protein HMX2, Homeobox protein Nkx-5.2
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P43687
Length: 273
Pfam Domains: 150-206 Homeobox domain
Sequence:
(in bold interface residues)
1 MGSKEDVGKGCPAAGGVSSFTIQSILGGGPSEAPREPAGWPARKRSLSVSSEEEEPEEGW 60
61 KAPACFCPDPHGPKEPSPKHHTPIPFPCLGTPKGSGGAGPAASERTPFLSPSHPDFKEEK 120
121 ERLLPAGSPSPGPERPRDGGAERQTGAAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERA 180
181 CLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVGMPLVFRDSSLLRV 240
241 PVPRSLAFPAPLYYPSSNLSALPLYNLYNKLDY
Interface Residues: 132, 133, 136, 149, 150, 151, 152, 153, 191, 192, 194, 195, 198, 199, 202, 203, 206
3D-footprint Homologues: 5zfz_A, 4j19_B, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 1fjl_B, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 2ld5_A, 6es3_K, 7q3o_C, 5zjt_E, 3a01_E, 5hod_A, 2hdd_A, 7psx_B, 5jlw_D, 3rkq_B, 2r5y_A, 1au7_A, 4xrs_G, 2hos_A, 4cyc_A, 1b72_A, 5flv_I, 3l1p_A, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 1o4x_A, 1le8_B, 6fqq_E, 1du0_A, 8g87_X, 4qtr_D, 1mnm_C, 1puf_B, 1k61_B, 6fqp_B
Binding Motifs: MA0897.1 / PH0042.1 acaAgCAATTAAwgvrT
MA0897.2 aAgCAATTAAwgvrT
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]

Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

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