Transcription Factor
| Accessions: | HIC1_MOUSE (HOCOMOCO 10), Q9R1Y5 (JASPAR 2024) |
| Names: | Hic-1, HIC1_MOUSE, Hypermethylated in cancer 1 protein |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9R1Y5 |
| Length: | 733 |
| Pfam Domains: | 37-152 BTB/POZ domain 440-459 C2H2-type zinc finger 507-529 C2H2-type zinc finger 507-527 Zinc-finger of C2H2 type 507-530 C2H2-type zinc finger 507-529 Zinc finger, C2H2 type 522-546 Zinc-finger double domain 535-557 C2H2-type zinc finger 535-558 C2H2-type zinc finger 535-557 Zinc finger, C2H2 type 537-557 Zinc-finger of C2H2 type 550-574 Zinc-finger double domain 563-585 C2H2-type zinc finger 563-583 C2H2-type zinc finger 563-585 Zinc finger, C2H2 type 578-601 Zinc-finger double domain 590-613 C2H2-type zinc finger 591-613 Zinc finger, C2H2 type 591-613 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MTFPEADILLKSGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRA 60 61 HKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLTDSVEAAAAAAVAP 120 121 GAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGSGGGGYAPYGRPGRGLRA 180 181 ATPVIQACYSSPAGPPPPPAAEPPSGPDAAVNTHCAELYASGPGPAASLCAPERRCSPLC 240 241 GLDLSKKSPPGSSVPERPLSERELPPRPDSPPGAGPAVYKEPSLALPPLPPLPFQKLEEA 300 301 VPTPDPFRGSGGSPGPEPPGRPDGSSLLYRWMKHEPGLGSYGDELVRDRGSPGERLEERG 360 361 GDPAASPGGPPLGLVPPPRYPGSLDGPGTGADGDDYKSSSEETGSSEDPSPPGGHLEGYP 420 421 CPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAA 480 481 GLGPPFGGGGDKVTGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTIC 540 541 GKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKF 600 601 AQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQL 660 661 SLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAA 720 721 GPDSRTIDRFSPT |
| Interface Residues: | 423, 426, 448, 449, 450, 454, 460, 462, 463, 466, 481, 485, 487, 488, 490, 491, 494, 517, 518, 519, 520, 521, 523, 524, 526, 527, 530, 535, 545, 546, 547, 548, 549, 552, 553, 573, 574, 575, 576, 577, 578, 579, 580, 581, 583, 584, 601, 602, 603, 604, 605, 607, 608, 609, 612 |
| 3D-footprint Homologues: | 5v3j_F, 7w1m_H, 7y3l_A, 1tf3_A, 8cuc_F, 8ssu_A, 1tf6_A, 6ml4_A, 6blw_A, 5kkq_D, 5ei9_F, 2drp_D, 5k5i_A, 8ssq_A, 2gli_A, 7eyi_G, 2lt7_A, 2i13_A, 6e94_A, 7ysf_A, 6wmi_A, 2jpa_A, 1ubd_C, 2kmk_A, 7n5w_A, 6jnm_A, 1g2f_F, 4x9j_A, 8gn3_A, 6u9q_A, 5yel_A, 1mey_C, 7txc_E, 5kl3_A, 5und_A, 8h9h_G, 4m9v_C, 7y3m_I, 6a57_A, 3uk3_C, 5k5l_F, 1llm_D, 2wbs_A, 1f2i_J, 5yj3_D |
| Binding Motifs: | PB0029.1 dykrTGCCAaCCtrcy PB0133.1 kggkrTGCCCawwmdv MA0739.1 rTGCCAaCc HIC1_MOUSE.H10MO.C|M01138 gGGkTGCCc MA0739.2 rTGCCAaC |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Pinte S., Stankovic-Valentin N., Deltour S., Rood B. R., Guerardel C., Leprince D. The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.. J. Biol. Chem. 279:38313-38324 (2004). [Pubmed] |
| Related annotations: | PaperBLAST |
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