Transcription Factor
| Accessions: | UP00263A (UniPROBE 20160601), HXB8_MOUSE (HOCOMOCO 10), P09632 (JASPAR 2024) |
| Names: | homeo box B8, Homeobox protein Hox-B8, Hox-2.4, Hoxb-8, Hoxb8, Homeobox protein Hox-2.4, HXB8_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | homeo box B8 |
| Length: | 243 |
| Pfam Domains: | 147-203 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MSSYFVNSLFSKYKTGESLRPNYYDCGFAQDLGGRPTVVYGPSSGGSFQHPSQIQEFYHG 60 61 PSSLSTAPYQQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDPDLVQYADCKLAAASGLGE 120 121 EAEGSEQSPSPTQLFPWMRPQAAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVS 180 181 HALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKEKLERAPETAEQGDAQKG 240 241 DKK |
| Interface Residues: | 146, 147, 148, 149, 150, 151, 188, 189, 191, 192, 195, 196, 199, 200, 203 |
| 3D-footprint Homologues: | 5zfz_A, 1fjl_B, 2h1k_B, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 3d1n_M, 1nk2_P, 1zq3_P, 6m3d_C, 3lnq_A, 2lkx_A, 1jgg_B, 2ld5_A, 2hos_A, 4cyc_A, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 4xrs_G, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 1k61_B, 1o4x_A, 8g87_X, 4qtr_D, 4xrm_B, 1mnm_C, 1du0_A |
| Binding Motifs: | UP00263A_1 wsykGyAATTAAtarw HXB8_MOUSE.H10MO.C|M01162 TTGATTrATkm PH0063.1 wsykGyAATTAAtarw |
| Binding Sites: | GGTAATTA AATAATTA AATTAATA AGTAATTA ATAATTAA ATAATTAC ATAATTAT ATTAATGA ATTAATTA ATTAATTG CATAATTA CATTAATG GCCATTAA GGCAATTA GTAATTAA GTAATTAC GTCATTAA TAATTATA TAATTGCA TTAATTAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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