Transcription Factor

Accessions: Q9UBX2 (JASPAR 2024)
Names: Double homeobox protein 10, Double homeobox protein 4, DUX4_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q9UBX2
Length: 424
Pfam Domains: 20-74 Homeobox domain
95-149 Homeobox domain
Sequence:
(in bold interface residues)
1 MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPE 60
61 PRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPG 120
121 IAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAF 180
181 AHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFA 240
241 YAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLA 300
301 PPTSQGSPWWGWGRGPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQ 360
361 EPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLEAPLSEEEYRAL 420
421 LEEL
Interface Residues: 20, 21, 23, 64, 65, 68, 69, 72, 73, 76, 95, 96, 97, 98, 136, 137, 139, 140, 143, 144, 147, 148, 151
3D-footprint Homologues: 3d1n_M, 3l1p_A, 5zfz_A, 1nk2_P, 1au7_A, 4j19_B, 5flv_I, 2xsd_C, 7xrc_C, 4xrm_B, 8g87_X, 6m3d_C, 3cmy_A, 6a8r_A, 1fjl_B, 2h1k_B, 1puf_A, 1jgg_B, 1zq3_P, 3lnq_A, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 1puf_B, 2hos_A, 5jlw_D, 4cyc_A, 4xrs_G, 1b72_A, 3a01_E, 1ig7_A, 5zjt_E, 1e3o_C, 1le8_A, 4qtr_D, 1du0_A
Binding Motifs: MA0468.1 TAAyyyAATCA
Binding Sites: MA0468.1.1
MA0468.1.10
MA0468.1.11
MA0468.1.12
MA0468.1.13
MA0468.1.14
MA0468.1.15
MA0468.1.16
MA0468.1.17
MA0468.1.18
MA0468.1.19
MA0468.1.2
MA0468.1.20
MA0468.1.3
MA0468.1.4
MA0468.1.5
MA0468.1.6
MA0468.1.7
MA0468.1.8
MA0468.1.9
Publications: Geng L.N, Yao Z, Snider L, Fong A.P, Cech J.N, Young J.M, van der Maarel S.M, Ruzzo W.L, Gentleman R.C, Tawil R, Tapscott S.J. DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy. Developmental cell 22:38-51 (2012). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.