Transcription Factor
Accessions: | Q9UBX2 (JASPAR 2024) |
Names: | Double homeobox protein 10, Double homeobox protein 4, DUX4_HUMAN |
Organisms: | Homo sapiens |
Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | Q9UBX2 |
Length: | 424 |
Pfam Domains: | 20-74 Homeobox domain 95-149 Homeobox domain |
Sequence: (in bold interface residues) | 1 MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPE 60 61 PRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPG 120 121 IAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAF 180 181 AHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFA 240 241 YAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLA 300 301 PPTSQGSPWWGWGRGPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQ 360 361 EPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLEAPLSEEEYRAL 420 421 LEEL |
Interface Residues: | 20, 21, 23, 64, 65, 68, 69, 72, 73, 76, 95, 96, 97, 98, 136, 137, 139, 140, 143, 144, 147, 148, 151 |
3D-footprint Homologues: | 3d1n_M, 3l1p_A, 5zfz_A, 1nk2_P, 1au7_A, 4j19_B, 5flv_I, 2xsd_C, 7xrc_C, 4xrm_B, 8g87_X, 6m3d_C, 3cmy_A, 6a8r_A, 1fjl_B, 2h1k_B, 1puf_A, 1jgg_B, 1zq3_P, 3lnq_A, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 1puf_B, 2hos_A, 5jlw_D, 4cyc_A, 4xrs_G, 1b72_A, 3a01_E, 1ig7_A, 5zjt_E, 1e3o_C, 1le8_A, 4qtr_D, 1du0_A |
Binding Motifs: | MA0468.1 TAAyyyAATCA |
Binding Sites: | MA0468.1.1 MA0468.1.10 MA0468.1.11 MA0468.1.12 MA0468.1.13 MA0468.1.14 MA0468.1.15 MA0468.1.16 MA0468.1.17 MA0468.1.18 MA0468.1.19 MA0468.1.2 MA0468.1.20 MA0468.1.3 MA0468.1.4 MA0468.1.5 MA0468.1.6 MA0468.1.7 MA0468.1.8 MA0468.1.9 |
Publications: | Geng L.N, Yao Z, Snider L, Fong A.P, Cech J.N, Young J.M, van der Maarel S.M, Ruzzo W.L, Gentleman R.C, Tawil R, Tapscott S.J. DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy. Developmental cell 22:38-51 (2012). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.