Transcription Factor
| Accessions: | T015233_1.02 (CISBP 1.02), COE1_HUMAN (HOCOMOCO 10), COE1_MOUSE (HOCOMOCO 10), Q07802 (JASPAR 2024), Q9UH73 (JASPAR 2024) |
| Names: | Ebf1, T015233_1.02;, COE1_HUMAN, Early B-cell factor, O/E-1, OE-1, Transcription factor COE1, COE1_MOUSE |
| Organisms: | Mus musculus, Homo sapiens |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | family:bHLH |
| Length: | 591 |
| Pfam Domains: | 262-344 IPT/TIG domain |
| Sequence: (in bold interface residues) | 1 MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPS 60 61 NLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGI 120 121 RTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDP 180 181 VIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKH 240 241 GRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLV 300 301 WSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRLQ 360 361 KVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQ 420 421 LPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSPHGYVPSTTPQQTN 480 481 YNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGI 540 541 FSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQAISGMIVPPM |
| Interface Residues: | 63, 65, 66, 163, 172, 202, 204, 236, 237, 238, 239, 349 |
| 3D-footprint Homologues: | 3mln_A, 3mlp_F, 2ypa_A |
| Binding Motifs: | MA0154.1 mCyCmaGGGA MA0154.3 AtTCCChwGGGAmt MA0154.2 kyCyCmwGGGa M3690_1.02 vdmdAbTCCCyrRrGrrbdkrb COE1_HUMAN.H10MO.A|M01056 argyCYCwgGGGAsh COE1_MOUSE.H10MO.C|M01037 sTCCCwGGGGAsy MA0154.4 wrTCCCCAGGGGAcw MA0154.5 TCCCCAGGGGA |
| Binding Sites: | MA0154.1.1 MA0154.1.10 MA0154.1.11 MA0154.1.12 MA0154.1.13 MA0154.1.14 MA0154.1.15 MA0154.1.16 MA0154.1.17 MA0154.1.18 MA0154.1.19 MA0154.1.2 MA0154.1.20 MA0154.1.3 MA0154.1.4 MA0154.1.5 MA0154.1.6 MA0154.1.7 MA0154.1.8 MA0154.1.9 MA0154.2.1 MA0154.2.10 MA0154.2.11 MA0154.2.12 MA0154.2.13 MA0154.2.14 MA0154.2.15 MA0154.2.16 MA0154.2.17 MA0154.2.18 MA0154.2.19 MA0154.2.2 MA0154.2.20 MA0154.2.3 MA0154.2.4 MA0154.2.5 MA0154.2.6 MA0154.2.7 MA0154.2.8 MA0154.2.9 MA0154.4.1 MA0154.4.10 / MA0154.4.5 MA0154.4.11 / MA0154.4.6 MA0154.4.12 / MA0154.4.9 MA0154.4.13 MA0154.4.10 / MA0154.4.14 MA0154.4.11 / MA0154.4.15 MA0154.4.16 MA0154.4.17 MA0154.4.18 MA0154.4.12 / MA0154.4.19 MA0154.4.1 / MA0154.4.2 MA0154.4.13 / MA0154.4.20 MA0154.4.3 MA0154.4.4 MA0154.4.3 / MA0154.4.5 MA0154.4.4 / MA0154.4.6 MA0154.4.7 MA0154.4.8 MA0154.4.9 MA0154.4.14 MA0154.4.15 MA0154.4.16 MA0154.4.17 MA0154.4.18 MA0154.4.19 MA0154.4.2 MA0154.4.20 MA0154.4.7 MA0154.4.8 MA0154.5.1 MA0154.5.10 MA0154.5.11 MA0154.5.12 MA0154.5.13 MA0154.5.14 MA0154.5.15 MA0154.5.16 MA0154.5.17 MA0154.5.18 MA0154.5.19 MA0154.5.2 MA0154.5.20 MA0154.5.3 / MA0154.5.5 MA0154.5.4 MA0154.5.6 MA0154.5.7 MA0154.5.8 MA0154.5.9 |
| Publications: | Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed] Travis A, Hagman J, Hwang L, Grosschedl R. Purification of early-B-cell factor and characterization of its DNA-binding specificity. Mol Cell Biol 13:3392-400 (1993). [Pubmed] |
| Related annotations: | PaperBLAST |
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