Transcription Factor
| Accessions: | Q62233 (JASPAR 2024) |
| Names: | Homeobox protein SIX3, Sine oculis homeobox homolog 3, SIX3_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q62233 |
| Length: | 333 |
| Pfam Domains: | 212-263 Homeobox domain 227-261 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MVFRSPLDLYSSHFLLPNFADSHHCSLLLASSGGGSGASGGGGGAGGGGGGNRAGGGGAG 60 61 GAGGGSGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAP 120 121 GACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEK 180 181 LRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKREL 240 241 AQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPST 300 301 AASPTTSVSSLTERADTGTSILSVTSSDSECDV |
| Interface Residues: | 202, 210, 211, 212, 213, 249, 250, 252, 253, 256, 257, 260, 261, 263, 264, 281 |
| 3D-footprint Homologues: | 4xrs_G, 1jgg_B, 1mnm_C, 2lkx_A, 2r5y_A, 1puf_B, 3l1p_A, 1le8_B, 1k61_B, 2ld5_A, 5jlw_D, 4j19_B, 2xsd_C, 7q3o_C, 1e3o_C, 1au7_A, 7xrc_C, 1le8_A, 1ig7_A, 7psx_B, 1du0_A, 5zfz_A, 6fqp_B, 5flv_I, 3lnq_A, 5zjt_E, 4qtr_D, 3a01_E, 1zq3_P, 6fqq_E, 5hod_A, 3rkq_B, 1nk2_P, 1fjl_B, 6a8r_A, 4xrm_B, 3cmy_A, 2h1k_B, 1b72_A, 4cyc_A, 1puf_A, 8g87_X, 6es3_K, 2hdd_A, 6m3d_C |
| Binding Motifs: | MA0631.1 / PH0163.1 rAtrGGGTATCAywwwt MA0631.2 AtrGGGTATCA |
| Publications: | Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.