Transcription Factor

Accessions: UP00477A (UniPROBE 20160601), P47043 (JASPAR 2024)
Names: Zap1, Zinc-responsive Activator Protein, ZRG10, ZAP1_YEAST
Organisms: Saccharomyces cerevisiae
Libraries: UniPROBE 20160601 1, JASPAR 2024 2
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Description: Zinc-responsive Activator Protein : Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains
Length: 880
Pfam Domains: 706-730 C2H2-type zinc finger
738-762 Zinc finger, C2H2 type
738-762 C2H2-type zinc finger
744-763 C2H2-type zinc finger
755-778 Zinc-finger double domain
767-791 C2H2-type zinc finger
768-790 Zinc finger, C2H2 type
783-806 Zinc-finger double domain
795-811 C2H2-type zinc finger
796-818 Zinc finger, C2H2 type
796-818 C2H2-type zinc finger
810-834 Zinc-finger double domain
824-846 C2H2-type zinc finger
825-846 Zinc finger, C2H2 type
825-846 C2H2-type zinc finger
838-859 Zinc-finger double domain
850-862 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 MDALTPRDSPKRDDSMATSAATAASAKPDALTIGKEGIVHGHIHNYNNLTYIHGHLHHSA 60
61 PVNDSSASATPAAAAVADAATSAFASGASHDMGGDCHVNEKCKEYTDCQHFEFLNYHNNP 120
121 SLTKYNDTATYNSNNHSFANNFHSVASDPTSPQQNSKSDLPRRKDSWFNDDLILLPSSKK 180
181 NKPNPPPGSDDCYCTPKILEICCDETHPKSEANIKQGESDQPTKKDISENGNDVAIFTDV 240
241 KNDHLMPNFNLHDQYCNSTNHDSHNHNNTVPDSFSQLMSHLSEIDCDLTCDTPCTASTSA 300
301 TSGHKFVQDHQSSNNDDVFHKYCKFCEESTDNQPCSKHMHLESKPPQLPPKCSSLRKPTN 360
361 TLQGTNHAYHEHILNTDMDLKILEDLCNISSLYEVPFGKHINHHDHNNAGNGCDGSSTGN 420
421 NENGNQTMNLLLSSINRCNPKNNLNGSNNNTAGATSTDHQHHHHRIQFHSHKPNRNNIVN 480
481 NSGISAANTTADLTNNDLNDLISREYSYERFRNQSEPPSLPKVTHQNQKNRRSWPTKDLE 540
541 STDFSSLEDSLPSSISPPIQTTSTINFNWCFKEEKNNDLKCKWKECPESCSSLFDLQRHL 600
601 LKDHVSQDFKHPMEPLACNWEDCDFLGDDTCSIVNHINCQHGINFDIQFANPDSFLPGSI 660
661 SKEKHHLLHCPNPQTHEVSKADGAPDMTSANDVSNIPPIKQPEQVICQWDGCNKSFSSAQ 720
721 ELNDHLEAVHLTRGKSEYQCLWHDCHRTFPQRQKLIRHLKVHSKYKPYKCKTCKRCFSSE 780
781 ETLVQHTRTHSGEKPYKCHICNKKFAISSSLKIHIRTHTGEKPLQCKICGKRFNESSNLS 840
841 KHIKTHQKKYKCSDCSKSFDDLGKLNSQKVKCALERKPYL
Interface Residues: 718, 720, 721, 723, 724, 726, 727, 733, 750, 751, 752, 753, 754, 757, 761, 768, 778, 779, 780, 781, 782, 784, 785, 806, 807, 808, 809, 810, 811, 812, 813, 814, 834, 835, 836, 837, 838, 839, 840, 841, 842, 845, 861, 862, 863, 864, 867
3D-footprint Homologues: 5yel_A, 6wmi_A, 5v3j_F, 2i13_A, 2jpa_A, 1tf3_A, 7w1m_H, 5kkq_D, 5ei9_F, 8ssq_A, 2gli_A, 8ssu_A, 1tf6_A, 6ml4_A, 7eyi_G, 6e94_A, 7ysf_A, 1ubd_C, 2kmk_A, 3uk3_C, 6jnm_A, 7n5w_A, 6blw_A, 6u9q_A, 1mey_C, 5kl3_A, 5und_A, 1g2f_F, 4x9j_A, 8h9h_G, 5k5i_A, 2lt7_A, 6a57_A, 8cuc_F, 7y3l_A, 2wbs_A, 7txc_E, 2drp_D, 1f2i_J, 5k5l_F, 8gn3_A, 1llm_D, 4m9v_C, 7y3m_I, 5yj3_D
Binding Motifs: UP00477A_1 / UP00477A_2 ktrrmwACCCTaadGGTymssa
UP00477A_3 GGTTAy
MA0440.1 ACCyTmArGGTyrTG
Binding Sites: AAGGTTAC
AGAGGTTA
AGGGTTAC
AAAGGTTA
AAGGGTTA
AAGGTTAT
AGGGGTTA
AGGGTTAT
AGGTTACC
AGGTTATG
ATAACCCC
ATAACCTC
CAGGGTTA
CATAACCC
CCATAACC
CGGGGTTA
CGTAACCC
GAGGTTAC
GGGTTATA
GGTTATGA
Publications: Gordân R, Murphy KF, McCord RP, Zhu C, Vedenko A, Bulyk ML. Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol : (2011). [Pubmed]

MacIsaac K.D, Wang T, Gordon D.B, Gifford D.K, Stormo G.D, Fraenkel E. An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC bioinformatics 7:113 (2006). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.