Transcription Factor

Accessions: ZFP3 (humanC2H2ZF-ChIP Feb2015), Q96NJ6 (JASPAR 2024)
Names: ENSG00000180787, Q96NJ6, ZFP3, Zfp-3, ZFP3_HUMAN, Zinc finger protein 3 homolog, Zinc finger protein 752
Organisms: Homo sapiens
Libraries: humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2
1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: TF family: C2H2 experiment: ChIP-seq/MEME/B1H-RC
Length: 502
Pfam Domains: 137-151 Zinc-finger double domain
140-164 C2H2-type zinc finger
141-163 Zinc finger, C2H2 type
141-163 C2H2-type zinc finger
156-180 Zinc-finger double domain
168-189 C2H2-type zinc finger
169-191 Zinc finger, C2H2 type
169-191 C2H2-type zinc finger
183-206 Zinc-finger double domain
197-219 Zinc finger, C2H2 type
215-235 Zinc-finger double domain
224-244 C2H2-type zinc finger
225-247 C2H2-type zinc finger
225-247 Zinc finger, C2H2 type
242-262 Zinc-finger double domain
252-273 C2H2-type zinc finger
253-275 C2H2-type zinc finger
253-275 Zinc finger, C2H2 type
270-292 Zinc-finger double domain
280-301 C2H2-type zinc finger
281-303 C2H2-type zinc finger
281-303 Zinc finger, C2H2 type
296-319 Zinc-finger double domain
309-329 C2H2-type zinc finger
309-331 C2H2-type zinc finger
309-331 Zinc finger, C2H2 type
324-347 Zinc-finger double domain
336-347 C2H2-type zinc finger
337-359 C2H2-type zinc finger
337-359 Zinc finger, C2H2 type
354-374 Zinc-finger double domain
365-387 C2H2-type zinc finger
365-387 Zinc finger, C2H2 type
365-379 C2H2-type zinc finger
380-403 Zinc-finger double domain
392-413 C2H2-type zinc finger
393-415 C2H2-type zinc finger
393-415 Zinc finger, C2H2 type
408-431 Zinc-finger double domain
421-443 C2H2-type zinc finger
436-459 Zinc-finger double domain
448-469 C2H2-type zinc finger
449-471 Zinc finger, C2H2 type
449-471 C2H2-type zinc finger
466-488 Zinc-finger double domain
476-500 C2H2-type zinc finger
477-499 Zinc finger, C2H2 type
477-499 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 MGTENKEVIPKEEISEESEPHGSLLEKFPKVVYQGHEFGAGCEEDMLEGHSRESMEEVIE 60
61 QMSPQERDFPSGLMIFKKSPSSEKDRENNESERGCSPSPNLVTHQGDTTEGVSAFATSGQ 120
121 NFLEILESNKTQRSSVGEKPHTCKECGKAFNQNSHLIQHMRVHSGEKPFECKECGKTFGT 180
181 NSSLRRHLRIHAGEKPFACNECGKAFIQSSHLIHHHRIHTGERPYKCEECGKAFSQNSAL 240
241 ILHQRIHTGEKPYECNECGKTFRVSSQLIQHQRIHTEERYHECNECGKAFKHSSGLIRHQ 300
301 KIHTGEKPYLCNECGKGFGQSSELIRHQRIHTGDKPYECNECGKTFGQNSEIIRHIRIHT 360
361 GEKPYVCKECGKAFRGNSELLRHERIHTGEKPYECFECGKAFRRTSHLIVHQRIHTGEKP 420
421 HQCNECARTFWDNSELLLHQKIHIGEKPYECSECEKTFSQHSQLIIHQRIHTGEKPYECQ 480
481 ECQKTFSRSSHLLRHQSVHCME
Interface Residues: 118, 120, 121, 124, 151, 152, 154, 155, 158, 162, 169, 179, 180, 181, 182, 183, 185, 186, 207, 208, 209, 210, 211, 213, 214, 217, 235, 236, 237, 238, 239, 241, 242, 246, 264, 266, 267, 270, 291, 292, 294, 295, 298, 319, 320, 321, 322, 323, 325, 326, 327, 330, 348, 349, 350, 351, 352, 354, 355, 357, 375, 376, 377, 378, 379, 381, 382, 388, 402, 404, 405, 406, 407, 409, 410, 412, 413, 414, 416, 431, 432, 433, 434, 435, 438, 460, 461, 462, 463, 466, 488, 489, 490, 491, 493, 494
3D-footprint Homologues: 6wmi_A, 3uk3_C, 1tf3_A, 5kl3_A, 5k5i_A, 1g2f_F, 8ssq_A, 1tf6_A, 1llm_D, 8ssu_A, 7ysf_A, 2kmk_A, 8gn3_A, 5yj3_D, 7w1m_H, 5und_A, 6ml4_A, 7y3m_I, 6e94_A, 2lt7_A, 1ubd_C, 1mey_C, 6u9q_A, 7txc_E, 5k5l_F, 5v3j_F, 8cuc_F, 7y3l_A, 5yel_A, 7n5w_A, 6jnm_A, 5ei9_F, 2drp_D, 1f2i_J, 4x9j_A, 2i13_A, 5kkq_D, 8h9h_G, 4m9v_C, 7eyi_G, 6a57_A, 6blw_A, 5no6_N, 2wbs_A, 2gli_A, 2jpa_A
Binding Motifs: ZFP3_ChIP AACTCCTAy
UN0153.1 gyrAACTCCTAytC
UN0153.2 rAACTCCTAytC
Binding Sites: UN0153.1.1
UN0153.1.10 / UN0153.1.8
UN0153.1.11 / UN0153.1.9
UN0153.1.10 / UN0153.1.12
UN0153.1.11 / UN0153.1.13
UN0153.1.12 / UN0153.1.14
UN0153.1.15
UN0153.1.13 / UN0153.1.16
UN0153.1.14 / UN0153.1.17
UN0153.1.15 / UN0153.1.18
UN0153.1.16 / UN0153.1.19
UN0153.1.2
UN0153.1.17 / UN0153.1.20
UN0153.1.2 / UN0153.1.3
UN0153.1.3 / UN0153.1.4
UN0153.1.4 / UN0153.1.5
UN0153.1.5 / UN0153.1.6
UN0153.1.7
UN0153.1.6 / UN0153.1.8
UN0153.1.7 / UN0153.1.9
UN0153.1.18
UN0153.1.19
UN0153.1.20
UN0153.2.1
UN0153.2.10 / UN0153.2.11
UN0153.2.12 / UN0153.2.16
UN0153.2.13
UN0153.2.14
UN0153.2.15 / UN0153.2.2
UN0153.2.17
UN0153.2.18 / UN0153.2.5 / UN0153.2.9
UN0153.2.19 / UN0153.2.6
UN0153.2.20
UN0153.2.3
UN0153.2.4
UN0153.2.7
UN0153.2.8
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.