Transcription Factor
| Accessions: | ETV1_HUMAN (HOCOMOCO 10), P50549 (JASPAR 2024) |
| Names: | ETS translocation variant 1, Ets-related protein 81, ETV1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P50549 |
| Length: | 477 |
| Pfam Domains: | 1-333 PEA3 subfamily ETS-domain transcription factor N terminal domain 335-416 Ets-domain |
| Sequence: (in bold interface residues) | 1 MDGFYDQQVPYMVTNSQRGRNCNEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAE 60 61 AQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSEISSACSQEQPFKFSYGEKCLYN 120 121 VSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNSTHTPKPDRAFPAHLPPSQSIPDSSY 180 181 PMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNT 240 241 MVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQ 300 301 FYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRG 360 361 MEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEA 420 421 LFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYVY |
| Interface Residues: | 387, 388, 390, 391, 392, 394, 395, 409 |
| 3D-footprint Homologues: | 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C |
| Binding Motifs: | MA0761.1 aCCGGAWrtr UN0568.1 rsCGGAAGTCRTAAAw UN0579.1 aCCGGATATGCAw ETV1_HUMAN.H10MO.B|M01125 ssrgrCmGGAAGyrrvgsssss MA0761.2 rraCAGGAAGTgrr MA0761.3 aCAGGAAGT UN0568.2 rsCGGAAGTCRTAAA UN0579.2 aCCGGATATGCA |
| Binding Sites: | MA0761.3.17 MA0761.3.20 MA0761.2.6 MA0761.2.7 MA0761.2.8 MA0761.2.2 / MA0761.2.3 MA0761.2.9 MA0761.2.3 / MA0761.2.4 MA0761.2.4 MA0761.2.1 MA0761.2.10 MA0761.2.11 / MA0761.2.9 MA0761.2.12 MA0761.2.10 / MA0761.2.13 MA0761.2.11 / MA0761.2.14 MA0761.2.15 MA0761.2.16 MA0761.2.17 MA0761.2.18 MA0761.2.19 MA0761.2.12 / MA0761.2.20 MA0761.2.5 MA0761.2.2 MA0761.2.13 MA0761.2.14 MA0761.2.15 MA0761.2.16 MA0761.2.17 MA0761.2.18 MA0761.2.19 MA0761.2.20 MA0761.3.1 / MA0761.3.9 MA0761.3.10 MA0761.3.11 MA0761.3.12 MA0761.3.13 MA0761.3.14 MA0761.3.15 MA0761.3.16 MA0761.3.18 MA0761.3.19 / MA0761.3.4 MA0761.3.2 MA0761.3.3 MA0761.3.5 MA0761.3.6 MA0761.3.7 MA0761.3.8 |
| Publications: | Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed] Cooper C.D, Newman J.A, Aitkenhead H, Allerston C.K, Gileadi O. Structures of the Ets Domains of Transcription Factors ETV1, ETV4, ETV5 and FEV: Determinants of DNA Binding and Redox Regulation by Disulfide bond formation. The Journal of biological chemistry : (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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