Transcription Factor

						

			
Accessions: Q02080 (JASPAR 2024)

			
Names: MEF2B_HUMAN, Myocyte-specific enhancer factor 2B, RSRFR2, Serum response factor-like protein 2
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q02080
Length: 365
Pfam Domains:     10-59 SRF-type transcription factor (DNA-binding and dimerisation domain)
Sequence: 
(in bold interface residues)		   1 MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYAST   60
  61 DMDRVLLKYTEYSEPHESRTNTDILETLKRRGIGLDGPELEPDEGPEEPGEKFRRLAGEG  120
 121 GDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEALPAQSRPSPFRPAAPKAGPP  180
 181 GLVHPLFSPSHLTSKTPPPLYLPTEGRRSDLPGGLAGPRGGLNTSRSLYSGLQNPCSTAT  240
 241 PGPPLGSFPFLPGGPPVGAEAWARRVPQPAAPPRRPPQSASSLSASLRPPGAPATFLRPS  300
 301 PIPCSSPGPWQSLCGLGPPCAGCPWPTAGPGRRSPGGTSPERSPGTARARGDPTSLQASS  360
 361 EKTQQ
Interface Residues: 3, 4, 15, 18, 19, 23, 160, 162, 164, 166
3D-footprint Homologues: 1c7u_A, 1hbx_A, 7x1n_C, 1n6j_A, 1mnm_A, 7cuh_A
Binding Motifs: MA0660.1 rCTAwAAATAGm
			
Publications: Katoh Y., Molkentin J. D., Dave V., Olson E. N., Periasamy M. MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression.. J. Biol. Chem. 273:1511-1518 (1998). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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