Transcription Factor

Accessions: ITF2_HUMAN (HOCOMOCO 10), P15884 (JASPAR 2024)
Names: bHLHb19, Class B basic helix-loop-helix protein 19, Immunoglobulin transcription factor 2, ITF-2, ITF2_HUMAN, SEF-2, SL3-3 enhancer factor 2, TCF-4, Transcription factor 4
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 667
Pfam Domains: 565-618 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWG 60
61 NGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQG 120
121 CHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGL 180
181 PSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAG 240
241 MLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPA 300
301 NGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTA 360
361 VWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHG 420
421 IIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQ 480
481 SATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKD 540
541 IKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKP 600
601 QTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDA 660
661 SNHMGQM
Interface Residues: 566, 569, 570, 572, 573, 574, 576, 577
3D-footprint Homologues: 7z5k_B, 2ypa_A, 7d8t_A, 6g1l_A, 6od3_F, 2ypa_B, 2ql2_A, 2ql2_D
Binding Motifs: MA0830.1 yrCACCTGbw
ITF2_HUMAN.H10MO.B|M01279 vCAGGTGyr
MA0830.2 cggCACCTGccss
MA0830.3 gCACCTGc
Binding Sites: MA0830.3.14 / MA0830.3.16 / MA0830.3.18
MA0830.3.4
MA0830.3.5
MA0830.3.8
MA0830.3.1
MA0830.3.11 / MA0830.3.12 / MA0830.3.13 / MA0830.3.19
MA0830.2.10 / MA0830.2.5
MA0830.2.1
MA0830.2.2
MA0830.2.4 / MA0830.2.5
MA0830.2.11 / MA0830.2.6
MA0830.2.12 / MA0830.2.7
MA0830.2.13 / MA0830.2.8
MA0830.2.10 / MA0830.2.14
MA0830.2.15
MA0830.2.16
MA0830.2.17
MA0830.2.18
MA0830.2.19
MA0830.2.11 / MA0830.2.20
MA0830.2.3
MA0830.2.3 / MA0830.2.4
MA0830.2.6
MA0830.2.7
MA0830.2.8
MA0830.2.9
MA0830.2.14
MA0830.2.18
MA0830.2.12
MA0830.2.13
MA0830.2.15
MA0830.2.16
MA0830.2.17
MA0830.2.19
MA0830.2.20
MA0830.2.9
MA0830.3.6
MA0830.3.15
MA0830.3.2
MA0830.3.10
MA0830.3.17
MA0830.3.20
MA0830.3.3
MA0830.3.7
MA0830.3.9
Publications: Kophengnavong T, Michnowicz J.E, Blackwell T.K. Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations. Molecular and cellular biology 20:261-72 (2000). [Pubmed]

Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res 47:8375-8387 (2019). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.