Transcription Factor

Accessions: T093250_1.02 (CISBP 1.02), P20719 (JASPAR 2024)
Names: HOXA5, T093250_1.02;, Homeobox protein Hox-1C, Homeobox protein Hox-A5, HXA5_HUMAN
Organisms: Homo sapiens, Mus musculus
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P20719
Notes: family:Homeodomain
Length: 270
Pfam Domains: 196-252 Homeobox domain
Sequence:
(in bold interface residues)
1 MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSG 60
61 SGHFGSGERARSYAASASAAPAEPRYSQPATSTHSPQPDPLPCSAVAPSPGSDSHHGGKN 120
121 SLSNSSGASADAGSTHISSREGVGTASGAEEDAPASSEQASAQSEPSPAPPAQPQIYPWM 180
181 RKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIK 240
241 IWFQNRRMKWKKDNKLKSMSMAAAGGAFRP
Interface Residues: 157, 158, 159, 162, 163, 178, 182, 196, 197, 198, 199, 237, 238, 240, 241, 244, 245, 248, 249, 252
3D-footprint Homologues: 3d1n_M, 5zfz_A, 1fjl_B, 6a8r_A, 2h1k_B, 1puf_A, 1ig7_A, 3cmy_A, 3lnq_A, 2lkx_A, 1jgg_B, 6m3d_C, 1zq3_P, 2ld5_A, 7q3o_C, 6es3_K, 1nk2_P, 3a01_E, 1b72_A, 5jlw_D, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 7psx_B, 5hod_A, 1le8_A, 7xrc_C, 1e3o_C, 2xsd_C, 1o4x_A, 4qtr_D, 1mnm_C, 1du0_A, 1k61_B, 3l1p_A
Binding Motifs: MA0158.1 CdbwAATk
M3428_1.02 tGrdskyghscAmTAATGrgGrwgwdkGCa
MA0158.2 symATTAs
Binding Sites: MA0158.1.1
MA0158.1.10
MA0158.1.11
MA0158.1.12
MA0158.1.13
MA0158.1.14
MA0158.1.15
MA0158.1.16
MA0158.1.2
MA0158.1.3
MA0158.1.4
MA0158.1.5
MA0158.1.6
MA0158.1.7
MA0158.1.8
MA0158.1.9
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]

Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed]
Related annotations: PaperBLAST

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