Transcription Factor
Accessions: | T093250_1.02 (CISBP 1.02), P20719 (JASPAR 2024) |
Names: | HOXA5, T093250_1.02;, Homeobox protein Hox-1C, Homeobox protein Hox-A5, HXA5_HUMAN |
Organisms: | Homo sapiens, Mus musculus |
Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | P20719 |
Notes: | family:Homeodomain |
Length: | 270 |
Pfam Domains: | 196-252 Homeobox domain |
Sequence: (in bold interface residues) | 1 MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSG 60 61 SGHFGSGERARSYAASASAAPAEPRYSQPATSTHSPQPDPLPCSAVAPSPGSDSHHGGKN 120 121 SLSNSSGASADAGSTHISSREGVGTASGAEEDAPASSEQASAQSEPSPAPPAQPQIYPWM 180 181 RKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIK 240 241 IWFQNRRMKWKKDNKLKSMSMAAAGGAFRP |
Interface Residues: | 157, 158, 159, 162, 163, 178, 182, 196, 197, 198, 199, 237, 238, 240, 241, 244, 245, 248, 249, 252 |
3D-footprint Homologues: | 3d1n_M, 5zfz_A, 1fjl_B, 6a8r_A, 2h1k_B, 1puf_A, 1ig7_A, 3cmy_A, 3lnq_A, 2lkx_A, 1jgg_B, 6m3d_C, 1zq3_P, 2ld5_A, 7q3o_C, 6es3_K, 1nk2_P, 3a01_E, 1b72_A, 5jlw_D, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 7psx_B, 5hod_A, 1le8_A, 7xrc_C, 1e3o_C, 2xsd_C, 1o4x_A, 4qtr_D, 1mnm_C, 1du0_A, 1k61_B, 3l1p_A |
Binding Motifs: | MA0158.1 CdbwAATk M3428_1.02 tGrdskyghscAmTAATGrgGrwgwdkGCa MA0158.2 symATTAs |
Binding Sites: | MA0158.1.1 MA0158.1.10 MA0158.1.11 MA0158.1.12 MA0158.1.13 MA0158.1.14 MA0158.1.15 MA0158.1.16 MA0158.1.2 MA0158.1.3 MA0158.1.4 MA0158.1.5 MA0158.1.6 MA0158.1.7 MA0158.1.8 MA0158.1.9 |
Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed] |
Related annotations: | PaperBLAST |
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