Transcription Factor
| Accessions: | TEAD4_HUMAN (HOCOMOCO 10), Q15561 (JASPAR 2024) |
| Names: | TEA domain family member 4, TEAD-4, TEAD4_HUMAN, Transcription factor 13-like 1, Transcription factor RTEF-1, Transcriptional enhancer factor TEF-3 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q15561 |
| Length: | 434 |
| Pfam Domains: | 15-426 TEA/ATTS domain family |
| Sequence: (in bold interface residues) | 1 MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPP 60 61 CGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQ 120 121 AAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPF 180 181 SQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPD 240 241 TYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWA 300 301 DLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYR 360 361 IHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSAS 420 421 EHGAQHHIYRLVKE |
| Interface Residues: | 74, 78, 95, 96, 99, 100, 103, 104, 107 |
| 3D-footprint Homologues: | 5gzb_A, 5no6_N |
| Binding Motifs: | MA0809.1 crmATTCCwy UN0581.1 GGwATGTTAATtr UN0582.1 rgAATGCGGAAGtr UN0583.1 rGAATsCGGAAGyg UN0585.1 rGaATGCGGAyrt UN0586.1 rGAATGCGGAAGTd TEAD4_HUMAN.H10MO.A|M01563 rMATTCCwggsat MA0809.2 ycACATTCCAgs MA0809.3 ACATTCCA UN0581.2 GGwATGTTAATt UN0582.2 rgAATGCGGAAGt UN0583.2 rGAATsCGGAAGy UN0585.2 rGaATGCGGAy UN0586.2 rGAATGCGGAAGT |
| Binding Sites: | MA0809.3.10 / MA0809.3.11 MA0809.3.1 / MA0809.3.12 / MA0809.3.15 / MA0809.3.2 / MA0809.3.5 / MA0809.3.8 MA0809.2.1 MA0809.2.10 MA0809.2.11 MA0809.2.12 / MA0809.2.6 MA0809.2.13 / MA0809.2.7 MA0809.2.14 MA0809.2.15 / MA0809.2.8 MA0809.2.16 MA0809.2.17 / MA0809.2.9 MA0809.2.10 / MA0809.2.18 MA0809.2.11 / MA0809.2.19 MA0809.2.2 MA0809.2.20 MA0809.2.2 / MA0809.2.3 MA0809.2.3 / MA0809.2.4 MA0809.2.4 / MA0809.2.5 MA0809.2.15 / MA0809.2.5 / MA0809.2.6 MA0809.2.7 MA0809.2.8 MA0809.2.9 MA0809.2.12 MA0809.2.13 MA0809.2.14 MA0809.2.16 MA0809.2.17 MA0809.2.18 MA0809.2.19 MA0809.2.20 MA0809.3.13 MA0809.3.14 / MA0809.3.16 / MA0809.3.17 / MA0809.3.3 / MA0809.3.4 MA0809.3.18 / MA0809.3.20 / MA0809.3.7 MA0809.3.19 MA0809.3.6 MA0809.3.9 |
| Publications: | Wasserman W.W, Fickett J.W. Identification of regulatory regions which confer muscle-specific gene expression. Journal of molecular biology 278:167-81 (1998). [Pubmed] Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.