Transcription Factor

Accessions: FOXA1_HUMAN (HOCOMOCO 10), P55317 (JASPAR 2024)
Names: Forkhead box protein A1, FOXA1_HUMAN, Hepatocyte nuclear factor 3-alpha, HNF-3-alpha, HNF-3A, TCF-3A, Transcription factor 3A
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P55317
Length: 472
Pfam Domains: 17-169 Forkhead N-terminal region
170-265 Fork head domain
397-461 HNF3 C-terminal domain
Sequence:
(in bold interface residues)
1 MLGTVKMEGHETSDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMT 60
61 PASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQ 120
121 AASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLIT 180
181 MAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGK 240
241 GSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKDPSGA 300
301 SNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGASELKTPASSTAPPI 360
361 SSGPGALASVPASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAY 420
421 EQALQYSPYGSTLPASLPLGSASVTTRSPIEPSALEPAYYQGVYSRPVLNTS
Interface Residues: 160, 162, 164, 165, 167, 213, 215, 216, 217, 219, 220, 221, 223, 224, 233, 240, 265
3D-footprint Homologues: 7yz7_A, 7yzb_A, 7vox_H, 2hdc_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 6el8_A, 7tdx_A, 3l2c_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 3qrf_G
Binding Motifs: FOXA1_HUMAN.H10MO.A|M01142 aTrTTTACwywgy
MA0148.1 TGTTTrCwywg
MA0148.2 TGTTTrCwywg
MA0148.3 tycwTRTTTACwywg
MA0148.4 awGTAAACATdw
MA0148.5 GTAAACAT
Binding Sites: MA0148.5.16
MA0148.5.10
MA0148.5.12 / MA0148.5.14 / MA0148.5.19 / MA0148.5.4
MA0148.5.18
MA0148.1.1
MA0148.1.10
MA0148.1.11
MA0148.1.12
MA0148.1.13
MA0148.1.14
MA0148.1.15
MA0148.1.16
MA0148.1.17
MA0148.1.18
MA0148.1.19
MA0148.1.2
MA0148.1.20
MA0148.1.3
MA0148.1.4
MA0148.1.5
MA0148.1.6
MA0148.1.7
MA0148.1.8
MA0148.1.9
MA0148.3.1
MA0148.3.10
MA0148.3.11
MA0148.3.12
MA0148.3.13
MA0148.3.14
MA0148.3.15
MA0148.3.16
MA0148.3.17
MA0148.3.18
MA0148.3.19
MA0148.3.2 / MA0148.3.3
MA0148.3.20
MA0148.3.4
MA0148.3.5
MA0148.3.6
MA0148.3.7
MA0148.3.8
MA0148.3.9
MA0148.4.16
MA0148.4.1
MA0148.4.10
MA0148.4.11 / MA0148.4.6
MA0148.4.12
MA0148.4.13
MA0148.4.14
MA0148.4.15 / MA0148.4.7
MA0148.4.16
MA0148.4.17
MA0148.4.18
MA0148.4.19 / MA0148.4.9
MA0148.4.1 / MA0148.4.2
MA0148.4.10 / MA0148.4.20
MA0148.4.2 / MA0148.4.3
MA0148.4.4
MA0148.4.5
MA0148.4.6
MA0148.4.3 / MA0148.4.7
MA0148.4.4 / MA0148.4.8
MA0148.4.5 / MA0148.4.9
MA0148.4.11
MA0148.4.12
MA0148.4.13
MA0148.4.14
MA0148.4.15
MA0148.4.17
MA0148.4.18
MA0148.4.19
MA0148.4.20
MA0148.4.8
MA0148.5.1
MA0148.5.11 / MA0148.5.3
MA0148.5.13 / MA0148.5.15
MA0148.5.17
MA0148.5.2 / MA0148.5.5
MA0148.5.20
MA0148.5.6
MA0148.5.7
MA0148.5.8
MA0148.5.9
Publications: Zhang Y, Liu T, Meyer C.A, Eeckhoute J, Johnson D.S, Bernstein B.E, Nusbaum C, Myers R.M, Brown M, Li W, Liu X.S. Model-based analysis of ChIP-Seq (MACS). Genome biology 9:R137 (2008). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.