Transcription Factor
Accessions: | NKX32_MOUSE (HOCOMOCO 10), P97503 (JASPAR 2024) |
Names: | Bagpipe homeobox protein homolog 1, Homeobox protein NK-3 homolog B, Homeobox protein Nkx-3.2, NKX32_MOUSE |
Organisms: | Mus musculus |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | P97503 |
Length: | 333 |
Pfam Domains: | 207-263 Homeobox domain |
Sequence: (in bold interface residues) | 1 MAVRGSGTLTPFSIQAILNKKEERGGLATPEGRPAPGGTEVAVTAAPAVCCWRIFGETEA 60 61 GALGGAEDSLLASPARTRTAVGQSAESPGGWDSDSALSEENEGRRRCADVPGASGTGRAR 120 121 VTLGLDQPGCELHAAKDLEEEAPVRSDSEMSASVSGDHSPRGEDDSVSPGGARVPGLRGA 180 181 AGSGASGGQAGGVEEEEEPAAPKPRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLA 240 241 ASLKLTETQVKIWFQNRRYKTKRRQMAADLLASAPAAKKVAVKVLVRDDQRQYLPGEVLR 300 301 PPSLLPLQPSYYYPYYCLPGWALSTCAAAAGTQ |
Interface Residues: | 127, 146, 147, 148, 151, 152, 205, 206, 207, 208, 209, 210, 248, 249, 251, 252, 255, 256, 259, 260, 263, 264, 265 |
3D-footprint Homologues: | 3d1n_M, 6fqp_B, 4j19_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 5zfz_A, 1ig7_A, 2h1k_B, 3lnq_A, 2lkx_A, 1jgg_B, 6m3d_C, 1nk2_P, 1zq3_P, 6es3_K, 2ld5_A, 7q3o_C, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 7psx_B, 4cyc_A, 1b72_A, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 1le8_A, 4qtr_D, 1mnm_C, 1puf_B, 8g87_X, 1k61_B, 1o4x_A, 1le8_B, 6fqq_E, 1du0_A, 5hod_A |
Binding Motifs: | NKX32_MOUSE.H10MO.C|M01249 arytAAGTGGv MA0122.1 ytrAGTRsm PH0004.1 mwtawSCACTTAavmay MA0122.3 wwaamCACTTAaw MA0122.4 aamCACTTAa |
Binding Sites: | MA0122.1.1 MA0122.1.10 MA0122.1.11 MA0122.1.12 MA0122.1.13 MA0122.1.14 MA0122.1.15 MA0122.1.16 MA0122.1.17 MA0122.1.18 MA0122.1.19 MA0122.1.2 MA0122.1.20 MA0122.1.3 MA0122.1.4 MA0122.1.5 MA0122.1.6 MA0122.1.7 MA0122.1.8 MA0122.1.9 MA0122.3.1 / MA0122.3.2 MA0122.3.10 / MA0122.3.12 MA0122.3.11 / MA0122.3.13 MA0122.3.12 / MA0122.3.14 / MA0122.3.16 MA0122.3.13 / MA0122.3.15 MA0122.3.15 / MA0122.3.17 MA0122.3.16 MA0122.3.17 / MA0122.3.18 MA0122.3.18 / MA0122.3.19 MA0122.3.19 MA0122.3.2 / MA0122.3.3 MA0122.3.20 MA0122.3.3 / MA0122.3.4 MA0122.3.4 / MA0122.3.5 MA0122.3.5 / MA0122.3.6 MA0122.3.6 / MA0122.3.7 MA0122.3.7 / MA0122.3.8 MA0122.3.10 / MA0122.3.8 MA0122.3.11 / MA0122.3.9 MA0122.3.1 MA0122.3.9 MA0122.4.1 MA0122.4.10 / MA0122.4.14 MA0122.4.11 / MA0122.4.13 / MA0122.4.15 MA0122.4.12 MA0122.4.16 MA0122.4.17 / MA0122.4.18 MA0122.4.19 / MA0122.4.6 MA0122.4.2 / MA0122.4.3 / MA0122.4.4 / MA0122.4.5 MA0122.4.20 MA0122.4.7 / MA0122.4.8 MA0122.4.9 |
Publications: | Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Kim D.W, Kempf H, Chen R.E, Lassar A.B. Characterization of Nkx3.2 DNA binding specificity and its requirement for somitic chondrogenesis. The Journal of biological chemistry 278:27532-9 (2003). [Pubmed] |
Related annotations: | PaperBLAST |
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