Transcription Factor

Accessions: NKX32_MOUSE (HOCOMOCO 10), P97503 (JASPAR 2024)
Names: Bagpipe homeobox protein homolog 1, Homeobox protein NK-3 homolog B, Homeobox protein Nkx-3.2, NKX32_MOUSE
Organisms: Mus musculus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P97503
Length: 333
Pfam Domains: 207-263 Homeobox domain
Sequence:
(in bold interface residues)
1 MAVRGSGTLTPFSIQAILNKKEERGGLATPEGRPAPGGTEVAVTAAPAVCCWRIFGETEA 60
61 GALGGAEDSLLASPARTRTAVGQSAESPGGWDSDSALSEENEGRRRCADVPGASGTGRAR 120
121 VTLGLDQPGCELHAAKDLEEEAPVRSDSEMSASVSGDHSPRGEDDSVSPGGARVPGLRGA 180
181 AGSGASGGQAGGVEEEEEPAAPKPRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLA 240
241 ASLKLTETQVKIWFQNRRYKTKRRQMAADLLASAPAAKKVAVKVLVRDDQRQYLPGEVLR 300
301 PPSLLPLQPSYYYPYYCLPGWALSTCAAAAGTQ
Interface Residues: 127, 146, 147, 148, 151, 152, 205, 206, 207, 208, 209, 210, 248, 249, 251, 252, 255, 256, 259, 260, 263, 264, 265
3D-footprint Homologues: 3d1n_M, 6fqp_B, 4j19_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 5zfz_A, 1ig7_A, 2h1k_B, 3lnq_A, 2lkx_A, 1jgg_B, 6m3d_C, 1nk2_P, 1zq3_P, 6es3_K, 2ld5_A, 7q3o_C, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 7psx_B, 4cyc_A, 1b72_A, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 1le8_A, 4qtr_D, 1mnm_C, 1puf_B, 8g87_X, 1k61_B, 1o4x_A, 1le8_B, 6fqq_E, 1du0_A, 5hod_A
Binding Motifs: NKX32_MOUSE.H10MO.C|M01249 arytAAGTGGv
MA0122.1 ytrAGTRsm
PH0004.1 mwtawSCACTTAavmay
MA0122.3 wwaamCACTTAaw
MA0122.4 aamCACTTAa
Binding Sites: MA0122.1.1
MA0122.1.10
MA0122.1.11
MA0122.1.12
MA0122.1.13
MA0122.1.14
MA0122.1.15
MA0122.1.16
MA0122.1.17
MA0122.1.18
MA0122.1.19
MA0122.1.2
MA0122.1.20
MA0122.1.3
MA0122.1.4
MA0122.1.5
MA0122.1.6
MA0122.1.7
MA0122.1.8
MA0122.1.9
MA0122.3.1 / MA0122.3.2
MA0122.3.10 / MA0122.3.12
MA0122.3.11 / MA0122.3.13
MA0122.3.12 / MA0122.3.14 / MA0122.3.16
MA0122.3.13 / MA0122.3.15
MA0122.3.15 / MA0122.3.17
MA0122.3.16
MA0122.3.17 / MA0122.3.18
MA0122.3.18 / MA0122.3.19
MA0122.3.19
MA0122.3.2 / MA0122.3.3
MA0122.3.20
MA0122.3.3 / MA0122.3.4
MA0122.3.4 / MA0122.3.5
MA0122.3.5 / MA0122.3.6
MA0122.3.6 / MA0122.3.7
MA0122.3.7 / MA0122.3.8
MA0122.3.10 / MA0122.3.8
MA0122.3.11 / MA0122.3.9
MA0122.3.1
MA0122.3.9
MA0122.4.1
MA0122.4.10 / MA0122.4.14
MA0122.4.11 / MA0122.4.13 / MA0122.4.15
MA0122.4.12
MA0122.4.16
MA0122.4.17 / MA0122.4.18
MA0122.4.19 / MA0122.4.6
MA0122.4.2 / MA0122.4.3 / MA0122.4.4 / MA0122.4.5
MA0122.4.20
MA0122.4.7 / MA0122.4.8
MA0122.4.9
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]

Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]

Kim D.W, Kempf H, Chen R.E, Lassar A.B. Characterization of Nkx3.2 DNA binding specificity and its requirement for somitic chondrogenesis. The Journal of biological chemistry 278:27532-9 (2003). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.