Transcription Factor

Accessions: T025277_1.02 (CISBP 1.02), ATF6A_HUMAN (HOCOMOCO 10), P18850 (JASPAR 2024)
Names: ATF6, T025277_1.02;, Activating transcription factor 6 alpha, ATF6-alpha, ATF6A_HUMAN, cAMP-dependent transcription factor ATF-6 alpha, Cyclic AMP-dependent transcription factor ATF-6 alpha
Organisms: Homo sapiens
Libraries: CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P18850
Notes: family:bZIP
Length: 670
Pfam Domains: 307-366 bZIP transcription factor
308-358 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 MGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDELQLEAANETYENNFDNL 60
61 DFDLDLMPWESDIWDINNQICTVKDIKAEPQPLSPASSSYSVSSPRSVDSYSSTQHVPEE 120
121 LDLSSSSQMSPLSLYGENSNSLSSAEPLKEDKPVTGPRNKTENGLTPKKKIQVNSKPSIQ 180
181 PKPLLLPAAPKTQTNSSVPAKTIIIQTVPTLMPLAKQQPIISLQPAPTKGQTVLLSQPTV 240
241 VQLQAPGVLPSAQPVLAVAGGVTQLPNHVVNVVPAPSANSPVNGKLSVTKPVLQSTMRNV 300
301 GSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGTLKRQLD 360
361 EVVSENQRLKVPSPKRRVVCVMIVLAFIILNYGPMSMLEQDSRRMNPSVSPANQRRHLLG 420
421 FSAKEAQDTSDGIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLN 480
481 HELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGS 540
541 ELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAINI 600
601 NENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAATEATH 660
661 VVSTIPESLQ
Interface Residues: 312, 316, 317, 319, 320, 323, 324
3D-footprint Homologues: 4eot_A, 7x5e_E, 7x5e_F, 1dh3_C, 2dgc_A
Binding Motifs: M2978_1.02 TGACGTGG
MA1466.1 tgrTGACGTGGCAs
ATF6A_HUMAN.H10MO.B|M01021 gkssTGACGTGG
MA1466.2 tgrTGACGTGGCA
Publications: Wang Y., Shen J., Arenzana N., Tirasophon W., Kaufman R. J., Prywes R. Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.. J. Biol. Chem. 275:27013-27020 (2000). [Pubmed]
Related annotations: PaperBLAST

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