Transcription Factor
| Accessions: | T093343_1.02 (CISBP 1.02), P78426 (JASPAR 2024) |
| Names: | NKX6-1, T093343_1.02;, Homeobox protein NK-6 homolog A, Homeobox protein Nkx-6.1, NKX61_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | family:Homeodomain |
| Length: | 367 |
| Pfam Domains: | 237-293 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP 60 61 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASP 120 121 SGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPS 180 181 AAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTR 240 241 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMA 300 301 TAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKITQLLKKHKSSSGGGGGLLLHA 360 361 SEPESSS |
| Interface Residues: | 235, 236, 237, 238, 240, 242, 278, 279, 281, 282, 285, 286, 289, 290, 292, 293, 303, 306 |
| 3D-footprint Homologues: | 5zfz_A, 3a01_E, 3cmy_A, 2ld5_A, 6a8r_A, 2h1k_B, 1puf_A, 1fjl_B, 3d1n_M, 2lkx_A, 1nk2_P, 1zq3_P, 7psx_B, 5jlw_D, 3lnq_A, 6es3_K, 4xrs_G, 2hdd_A, 7q3o_C, 1b72_A, 3rkq_B, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 1jgg_B, 5hod_A, 3l1p_A, 1mnm_C, 1e3o_C, 1le8_A, 1au7_A, 1ig7_A, 7xrc_C, 2xsd_C, 1o4x_A, 8g87_X, 4qtr_D, 1du0_A, 6wig_A, 6m3d_C |
| Binding Motifs: | MA0674.1 sYmATTAa M3640_1.02 twTTTAATTGgwT MA0674.2 YmATTAa |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.