Transcription Factor
| Accessions: | SP2_HUMAN (HOCOMOCO 10), Q02086 (JASPAR 2024) |
| Names: | SP2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q02086 |
| Length: | 613 |
| Pfam Domains: | 525-549 Zinc finger, C2H2 type 525-549 C2H2-type zinc finger 542-568 Zinc-finger double domain 555-579 Zinc finger, C2H2 type 555-579 C2H2-type zinc finger 572-594 Zinc-finger double domain 585-607 Zinc finger, C2H2 type 585-607 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MSDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPP 60 61 QPTPRKLVPIKPAPLPLSPGKNSFGILSSKGNILQIQGSQLSASYPGGQLVFAIQNPTMI 120 121 NKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAIITPSPSSHKPVPIK 180 181 PAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPTQLLTESPPTPL 240 241 SKTNKKARKKSLPASQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQ 300 301 VQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPTPTQVYIRTPS 360 361 GEVQTVLVQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAPAGS 420 421 IISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPT 480 481 QIQLQMEQALAGETQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKTS 540 541 LLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHL 600 601 TKHYKTHLVTKNL |
| Interface Residues: | 511, 515, 516, 517, 518, 519, 522, 526, 537, 538, 539, 540, 541, 543, 544, 546, 547, 550, 567, 568, 569, 570, 571, 573, 574, 575, 578, 593, 595, 596, 597, 598, 599, 600, 601, 602, 603 |
| 3D-footprint Homologues: | 7ysf_A, 2i13_A, 5v3j_F, 5kkq_D, 7eyi_G, 8cuc_F, 1tf3_A, 7y3l_A, 6ml4_A, 7n5w_A, 6jnm_A, 3uk3_C, 5k5i_A, 2kmk_A, 2gli_A, 8gn3_A, 1g2f_F, 6blw_A, 1tf6_A, 6u9q_A, 5yel_A, 4x9j_A, 5kl3_A, 1ubd_C, 6wmi_A, 5ei9_F, 1mey_C, 5und_A, 8h9h_G, 8ssu_A, 2lt7_A, 7y3m_I, 6e94_A, 8ssq_A, 7w1m_H, 6a57_A, 2jpa_A, 2drp_D, 1f2i_J, 1llm_D, 7txc_E, 2wbs_A, 5yj3_D, 4m9v_C |
| Binding Motifs: | MA0516.1 gyCCCGCCyCyyccs MA0516.2 mTAAGyCCCGCCCmCyy SP2_HUMAN.H10MO.C|M01525 sgssrgGrGGCGGGgccggsgs MA0516.3 GGGGCGGGg |
| Binding Sites: | MA0516.1.1 MA0516.1.10 MA0516.1.11 MA0516.1.12 MA0516.1.13 MA0516.1.14 MA0516.1.15 MA0516.1.16 MA0516.1.17 MA0516.1.18 MA0516.1.19 MA0516.1.2 MA0516.1.20 MA0516.1.3 MA0516.1.4 MA0516.1.5 MA0516.1.6 MA0516.1.7 MA0516.1.8 MA0516.1.9 |
| Publications: | Moorefield K. S., Fry S. J., Horowitz J. M. Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells.. J. Biol. Chem. 279:13911-13924 (2004). [Pubmed] Terrados G, Finkernagel F, Stielow B, Sadic D, Neubert J, Herdt O, Krause M, Scharfe M, Jarek M, Suske G. Genome-wide localization and expression profiling establish Sp2 as a sequence-specific transcription factor regulating vitally important genes. Nucleic acids research 40:7844-57 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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