Transcription Factor
| Accessions: | Q96JB3 (JASPAR 2024) |
| Names: | Hic-2, Hic-3, HIC1-related gene on chromosome 22 protein, HIC2_HUMAN, Hypermethylated in cancer 2 protein, Zinc finger and BTB domain-containing protein 30 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q96JB3 |
| Length: | 615 |
| Pfam Domains: | 36-141 BTB/POZ domain 447-464 C2H2-type zinc finger 505-528 C2H2-type zinc finger 505-527 Zinc finger, C2H2 type 505-527 C2H2-type zinc finger 505-525 Zinc-finger of C2H2 type 520-543 Zinc-finger double domain 533-556 C2H2-type zinc finger 533-555 Zinc finger, C2H2 type 533-555 C2H2-type zinc finger 535-555 Zinc-finger of C2H2 type 548-572 Zinc-finger double domain 561-584 C2H2-type zinc finger 561-583 Zinc finger, C2H2 type 561-583 C2H2-type zinc finger 576-599 Zinc-finger double domain 588-612 C2H2-type zinc finger 589-611 C2H2-type zinc finger 589-611 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MVSGPLALRWCAWAGRGDMGPDMELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAH 60 61 KNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLPSDQPAEPNFSTLL 120 121 TAASYLQLPELAALCRRKLKRAGKPFGSGRAGSTGMGRPPRSQRLSTASVIQARYQGLVD 180 181 GRKGAHAPQELPQAKGSDDELFLGGSNQDSVQGLGRAVCPAGGEAGLGGCSSSTNGSSGG 240 241 CEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDSQHGSPPAASAPPVANSASYSELGG 300 301 TPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREAGPKGP 360 361 CPGEEGEGVGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGGSGH 420 421 ASAHYMYRQEGYETVSYGDNLYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETG 480 481 SGGAEEEAEDLSAPSAAYTAEPRPFKCSVCEKTYKDPATLRQHEKTHWLTRPFPCNICGK 540 541 MFTQRGTMTRHMRSHLGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQ 600 601 QRNLISHLRMHTSPS |
| Interface Residues: | 453, 455, 459, 487, 488, 489, 491, 507, 509, 515, 516, 517, 518, 519, 521, 522, 524, 525, 528, 533, 543, 544, 545, 546, 547, 550, 551, 571, 572, 573, 574, 575, 576, 577, 578, 579, 581, 582, 585, 586, 599, 600, 601, 602, 603, 605, 606, 609 |
| 3D-footprint Homologues: | 7w1m_H, 5v3j_F, 2gli_A, 7y3l_A, 8cuc_F, 8ssu_A, 6ml4_A, 8gn3_A, 5kkq_D, 5ei9_F, 2drp_D, 5k5i_A, 8ssq_A, 1tf6_A, 7eyi_G, 2lt7_A, 2i13_A, 6e94_A, 7ysf_A, 6wmi_A, 2jpa_A, 1ubd_C, 2kmk_A, 7n5w_A, 1tf3_A, 6jnm_A, 4x9j_A, 1mey_C, 6blw_A, 6u9q_A, 5yel_A, 7txc_E, 5kl3_A, 1g2f_F, 5und_A, 1llm_D, 8h9h_G, 4m9v_C, 7y3m_I, 6a57_A, 3uk3_C, 2wbs_A, 1f2i_J, 5yj3_D, 5k5l_F, 1yuj_A |
| Binding Motifs: | MA0738.1 rTGCCMrsy MA0738.2 rTGCCM |
| Publications: | Pinte S., Stankovic-Valentin N., Deltour S., Rood B. R., Guerardel C., Leprince D. The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.. J. Biol. Chem. 279:38313-38324 (2004). [Pubmed] |
| Related annotations: | PaperBLAST |
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