Transcription Factor

Accessions: IRF9 (HT-SELEX2 May2017), IRF9_HUMAN (HOCOMOCO 10), Q00978 (JASPAR 2024)
Names: ENSG00000213928, IRF9, IFN-alpha-responsive transcription factor subunit, Interferon regulatory factor 9, Interferon-stimulated gene factor 3 gamma, IRF-9, IRF9_HUMAN, ISGF-3 gamma, ISGF3 p48 subunit, Transcriptional regulator ISGF3 subunit gamma
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, HOCOMOCO 10 2, JASPAR 2024 3
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: TF family: IRF experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: IRF experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3
Length: 393
Pfam Domains: 11-116 Interferon regulatory factor transcription factor
218-382 Interferon-regulatory factor 3
Sequence:
(in bold interface residues)
1 MASGRARCTRKLRNWVVEQVESGQFPGVCWDDTAKTMFRIPWKHAGKQDFREDQDAAFFK 60
61 AWAIFKGKYKEGDTGGPAVWKTRLRCALNKSSEFKEVPERGRMDVAEPYKVYQLLPPGIV 120
121 SGQPGTQKVPSKRQHSSVSSERKEEEDAMQNCTLSPSVLQDSLNNEEEGASGGAVHSDIG 180
181 SSSSSSSPEPQEVTDTTEAPFQGDQRSLEFLLPPEPDYSLLLTFIYNGRVVGEAQVQSLD 240
241 CRLVAEPSGSESSMEQVLFPKPGPLEPTQRLLSQLERGILVASNPRGLFVQRLCPIPISW 300
301 NAPQAPPGPGPHLLPSNECVELFRTAYFCRDLVRYFQGLGPPPKFQVTLNFWEESHGSSH 360
361 TPQNLITVKMEQAFARYLLEQTPEQQAAILSLV
Interface Residues: 44, 46, 78, 82, 83, 85, 86, 89, 90
3D-footprint Homologues: 2pi0_B, 1if1_B, 2irf_L, 7oot_B, 2o61_A
Binding Motifs: MA0653.1 AwCGAAACCGAAACy
IRF9_2 aCGAAAsyGAAASyr
IRF9_methyl_1 ryGAAAsyGAAASyw
IRF9_HUMAN.H10MO.C|M01273 GAAAgcGAAAyT
Publications: Marquis JF, Kapoustina O, Langlais D, Ruddy R, Dufour CR, Kim BH, MacMicking JD, Giguère V, Gros P. Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis. PLoS Genet : (2011). [Pubmed]
Related annotations: PaperBLAST

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