Transcription Factor

Accessions: Q8N5J4 (JASPAR 2024)
Names: SPIC_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 248
Pfam Domains: 111-195 Ets-domain
Sequence:
(in bold interface residues)
1 MTCVEQDKLGQAFEDAFEVLRQHSTGDLQYSPDYRNYLALINHRPHVKGNSSCYGVLPTE 60
61 EPVYNWRTVINSAADFYFEGNIHQSLQNITENQLVQPTLLQQKGGKGRKKLRLFEYLHES 120
121 LYNPEMASCIQWVDKTKGIFQFVSKNKEKLAELWGKRKGNRKTMTYQKMARALRNYGRSG 180
181 EITKIRRKLTYQFSEAILQRLSPSYFLGKEIFYSQCVQPDQEYLSLNNWNANYNYTYANY 240
241 HELNHHDC
Interface Residues: 120, 150, 167, 168, 170, 171, 172, 174, 175, 188
3D-footprint Homologues: 8amd_A, 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 7jsa_J, 3jtg_A, 1dux_F, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B
Binding Motifs: MA0687.1 aaAAWsmGGAAGTa
MA0687.2 aAAWsmGGAAGTa
Publications: Schweitzer BL, Huang KJ, Kamath MB, Emelyanov AV, Birshtein BK, DeKoter RP. Spi-C has opposing effects to PU. 1 on gene expression in progenitor B cells 177:2195-207 (J). [Pubmed]
Related annotations: PaperBLAST

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