Transcription Factor
| Accessions: | P09065 (JASPAR 2024) |
| Names: | HME1_MOUSE, Homeobox protein en-1, Homeobox protein engrailed-1, Mo-En-1 |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P09065 |
| Length: | 401 |
| Pfam Domains: | 313-369 Homeobox domain 370-401 Engrailed homeobox C-terminal signature domain |
| Sequence: (in bold interface residues) | 1 MEEQQPEPKSQRDSGLGAVAAAAPSGLSLSLSPGASGSSGSDGDSVPVSPQPAPPSPPAA 60 61 PCLPPLAHHPHLPPHPPPPPPPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFG 120 121 CKKEQPLPQLLVASAAAGGGAAAGGGSRVERDRGQTGAGRDPVHSLGTRASGAASLLCAP 180 181 DANCGPPDGSQPATAVSAGASKAGNPAAAAAAAAAAAAAAVAAAAAAASKPSDSGGGSGG 240 241 NAGSPGAQGAKFPEHNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRT 300 301 RKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWF 360 361 QNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDESE |
| Interface Residues: | 300, 313, 314, 315, 316, 354, 355, 357, 358, 361, 362, 365, 366, 369 |
| 3D-footprint Homologues: | 5zfz_A, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 1fjl_B, 6fqp_B, 1ig7_A, 2h1k_B, 2lkx_A, 1jgg_B, 6m3d_C, 1nk2_P, 1zq3_P, 3lnq_A, 2ld5_A, 5hod_A, 3rkq_B, 2hdd_A, 5jlw_D, 4cyc_A, 2r5y_A, 1puf_B, 6es3_K, 1au7_A, 4xrs_G, 2hos_A, 7psx_B, 4j19_B, 1b72_A, 5flv_I, 7q3o_C, 5zjt_E, 3a01_E, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 1le8_B, 6fqq_E, 1du0_A, 4xrm_B, 1mnm_C, 8g87_X, 1k61_B, 1o4x_A, 4qtr_D |
| Binding Motifs: | MA0027.1 waRTdRWkbyc PH0028.1 gsvAAcTAATTArkgc |
| Binding Sites: | MA0027.1.1 MA0027.1.10 MA0027.1.2 MA0027.1.3 MA0027.1.4 MA0027.1.5 MA0027.1.6 MA0027.1.7 MA0027.1.8 MA0027.1.9 |
| Publications: | Catron K. M., Iller N., Abate C. Nucleotides flanking a conserved TAAT core dictate the DNA binding specifity of three murine homeodomain proteins. Mol. Cell. Biol. 13:2354-2365 (1993). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.