Transcription Factor

						

			
Accessions: ETS2_TF1 (HumanTF2 1.0)

			
Names: ETS2, ETS2_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: P15036
Notes: Ensembl ID: ENSG00000157557; Construct type: TF1(SBP); TF family: ETS; Clone source: Megaman
Length: 399
Pfam Domains:     18-99 Sterile alpha motif (SAM)/Pointed domain
  293-374 Ets-domain
Sequence: 
(in bold interface residues)		   1 LTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQ   60
  61 RFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEENSHLTSVPHW  120
 121 INSNTLGFGTEQAPYGMQTQNYPKGGLLDSMCPASTPSVLSSEQEFQMFPKSRLSSVSVT  180
 181 YCSVSQDFPGSNLNLLTNNSGTPKDHDSPENGADSFESSDSLLQSWNSQSSLLDVQRVPS  240
 241 FESFEDDCSQSLCLNKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGVGPIQLWQFLL  300
 301 ELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNII  360
 361 HKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED
Interface Residues: 87, 103, 124, 128, 280, 345, 346, 348, 349, 350, 352, 353, 367
3D-footprint Homologues: 1lrr_A, 3fmt_B, 3zdb_A, 4uno_A, 2stt_A, 7jsa_J, 3zp5_A, 1dux_F, 8ee9_F, 4mhg_A, 3jtg_A, 1bc8_C, 4l18_B, 4lg0_B, 4bqa_A, 1awc_A, 4iri_A, 1yo5_C
Binding Motifs: ETS2 rCCGGAAGTg
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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