Transcription Factor
| Accessions: | MEF2A_HUMAN (HOCOMOCO 10), EAX02249 (JASPAR 2024), Q02078 (JASPAR 2024) |
| Names: | MEF2A_HUMAN, Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1, A0A0S2Z453_HUMAN, Fragment, MADS box transcription enhancer factor 2, polypeptide A, Myocyte enhancer factor 2A, Myocyte enhancer factor 2A isoform 2 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 507 |
| Pfam Domains: | 10-59 SRF-type transcription factor (DNA-binding and dimerisation domain) 90-154 Holliday junction regulator protein family C-terminal repeat |
| Sequence: (in bold interface residues) | 1 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST 60 61 DMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPDTSYVLTPHTEEKYKKINE 120 121 EFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSML 180 181 SPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIG 240 241 ATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLSEEEELELNTQR 300 301 ISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLS 360 361 LGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQ 420 421 QQQQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSP 480 481 IVLGRPPNTEDRESPSVKRMRMDAWVT |
| Interface Residues: | 3, 4, 15, 18, 19, 23, 274, 276 |
| 3D-footprint Homologues: | 1n6j_A, 1c7u_A, 1hbx_A, 7x1n_C, 1mnm_A, 6fas_B |
| Binding Motifs: | MA0052.3 kCTAwAAATAGm MA0052.2 dkCyAAAAATAGmhy MEF2A_HUMAN.H10MO.A|M01319 dkCTATTTTTrGm MA0052.1 CTATTTwTAG MA0052.4 wkcTAAAAATAGaww MA0052.5 cTAAAAATAG |
| Binding Sites: | MA0052.1.1 MA0052.1.10 MA0052.1.11 MA0052.1.12 MA0052.1.13 MA0052.1.14 MA0052.1.15 MA0052.1.16 MA0052.1.17 MA0052.1.18 MA0052.1.19 MA0052.1.2 MA0052.1.20 MA0052.1.3 MA0052.1.4 MA0052.1.5 MA0052.1.6 MA0052.1.7 MA0052.1.8 MA0052.1.9 MA0052.2.1 MA0052.2.10 MA0052.2.11 MA0052.2.12 MA0052.2.13 MA0052.2.14 MA0052.2.15 MA0052.2.16 MA0052.2.17 MA0052.2.18 MA0052.2.19 MA0052.2.2 MA0052.2.20 MA0052.2.3 MA0052.2.4 MA0052.2.5 MA0052.2.6 MA0052.2.7 MA0052.2.8 MA0052.2.9 MA0052.4.1 MA0052.4.10 MA0052.4.11 MA0052.4.12 MA0052.4.13 / MA0052.4.8 MA0052.4.14 / MA0052.4.9 MA0052.4.10 / MA0052.4.15 MA0052.4.11 / MA0052.4.16 MA0052.4.17 MA0052.4.12 / MA0052.4.18 MA0052.4.13 / MA0052.4.19 MA0052.4.2 MA0052.4.20 MA0052.4.3 MA0052.4.3 / MA0052.4.4 MA0052.4.4 / MA0052.4.5 MA0052.4.5 / MA0052.4.6 MA0052.4.6 / MA0052.4.7 MA0052.4.8 MA0052.4.7 / MA0052.4.9 MA0052.4.14 MA0052.4.15 MA0052.4.16 MA0052.4.17 MA0052.4.18 MA0052.4.19 MA0052.4.20 MA0052.5.1 MA0052.5.10 / MA0052.5.16 / MA0052.5.2 / MA0052.5.3 / MA0052.5.5 MA0052.5.11 MA0052.5.12 MA0052.5.13 MA0052.5.14 MA0052.5.15 / MA0052.5.18 MA0052.5.17 MA0052.5.19 / MA0052.5.20 MA0052.5.4 / MA0052.5.9 MA0052.5.6 MA0052.5.7 MA0052.5.8 |
| Publications: | Pollock R., Treisman R. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. Genes Dev. 5:2327-2341 (1991). [Pubmed] Wales S, Hashemi S, Blais A, McDermott JC. Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling. Nucleic Acids Res 42:11349-62 (2014). [Pubmed] |
| Related annotations: | PaperBLAST |
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