Transcription Factor
| Accessions: | T093403_1.02 (CISBP 1.02), O15266 (JASPAR 2024) |
| Names: | SHOX, T093403_1.02;, Pseudoautosomal homeobox-containing osteogenic protein, Short stature homeobox protein, Short stature homeobox-containing protein, SHOX_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Homeodomain |
| Length: | 292 |
| Pfam Domains: | 118-174 Homeobox domain 271-289 OAR domain |
| Sequence: (in bold interface residues) | 1 MEELTAFVSKSFDQKSKDGNGGGGGGGGKKDSITYREVLESGLARSRELGTSDSSLQDIT 60 61 EGGGHCPVHLFKDHVDNDKEKLKEFGTARVAEGIYECKEKREDVKSEDEDGQTKLKQRRS 120 121 RTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQMH 180 181 KGVILGTANHLDACRVAPYVNMGALRMPFQQVQAQLQLEGVAHAHPHLHPHLAAHAPYLM 240 241 FPPPPFGLPIASLAESASAAAVVAAAAKSNSKNSSIADLRLKARKHAEALGL |
| Interface Residues: | 117, 118, 119, 120, 121, 159, 160, 162, 163, 166, 167, 170, 171, 174 |
| 3D-footprint Homologues: | 4j19_B, 5zfz_A, 2h1k_B, 6fqp_B, 1puf_A, 5zjt_E, 3cmy_A, 1fjl_B, 6a8r_A, 3d1n_M, 1ig7_A, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 1nk2_P, 1zq3_P, 7q3o_C, 6es3_K, 2ld5_A, 7psx_B, 3a01_E, 5flv_I, 2hdd_A, 1au7_A, 5hod_A, 3rkq_B, 2r5y_A, 1puf_B, 2hos_A, 6wig_A, 1b72_A, 5jlw_D, 4cyc_A, 4xrs_G, 3l1p_A, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 1o4x_A, 1du0_A, 4qtr_D, 4xrm_B, 8g87_X |
| Binding Motifs: | M0900_1.02 yTAATTrr MA0630.1 yTAATTrr MA0630.2 TAATTr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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