Transcription Factor
| Accessions: | MYC_MOUSE (HOCOMOCO 10), P01108 (JASPAR 2024) |
| Names: | Myc proto-oncogene protein, MYC_MOUSE, Proto-oncogene c-Myc, Transcription factor p64 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 439 |
| Pfam Domains: | 1-345 Myc amino-terminal region 355-407 Helix-loop-helix DNA-binding domain 408-438 Myc leucine zipper domain |
| Sequence: (in bold interface residues) | 1 MPLNVNFTNRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAPSEDIWKKFELLPTPP 60 61 LSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTELLGGDMVNQSFICDP 120 121 DDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSPARGHSVCSTSSLYLQ 180 181 DLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSPSSDSLLSSESSPRASPEPLVL 240 241 HEETPPTTSSDSEEEQEDEEEIDVVSVEKRQTPAKRSESGSSPSRGHSKPPHSPLVLKRC 300 301 HVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSSPRSSDTEENDKRRTHN 360 361 VLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSIQADEHKLTSEKDLL 420 421 RKRREQLKHKLEQLRNSGA |
| Interface Residues: | 356, 359, 360, 362, 363, 366, 367, 391 |
| 3D-footprint Homologues: | 7z5k_B, 7d8t_A, 4zpk_A, 5nj8_D, 7rcu_E, 5eyo_A, 5v0l_A, 1am9_A, 7xi3_A, 6g1l_A, 5i50_B, 1an4_A, 5gnj_I |
| Binding Motifs: | MA0147.1 mgCACGTGGc MYC_MOUSE.H10MO.A|M01219 gsrasCACrTGG MA0147.2 CCAyGTGsty |
| Binding Sites: | MA0147.1.1 MA0147.1.10 MA0147.1.11 MA0147.1.12 MA0147.1.13 MA0147.1.14 MA0147.1.15 MA0147.1.16 MA0147.1.17 MA0147.1.18 MA0147.1.19 MA0147.1.2 MA0147.1.20 MA0147.1.3 MA0147.1.4 MA0147.1.5 MA0147.1.6 MA0147.1.7 MA0147.1.8 MA0147.1.9 MA0147.2.1 MA0147.2.10 MA0147.2.11 MA0147.2.12 MA0147.2.13 MA0147.2.14 MA0147.2.15 MA0147.2.16 MA0147.2.17 MA0147.2.18 MA0147.2.19 MA0147.2.2 MA0147.2.20 MA0147.2.3 MA0147.2.4 MA0147.2.5 MA0147.2.6 MA0147.2.7 MA0147.2.8 MA0147.2.9 |
| Publications: | Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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