Transcription Factor

Accessions: FOXP2_HUMAN (HOCOMOCO 10), O15409 (JASPAR 2024)
Names: CAG repeat protein 44, Forkhead box protein P2, FOXP2_HUMAN, Trinucleotide repeat-containing gene 10 protein
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: O15409
Length: 715
Pfam Domains: 504-587 Fork head domain
Sequence:
(in bold interface residues)
1 MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQA 60
61 ARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQA 120
121 LLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 180
181 QQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQG 240
241 LISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTT 300
301 SSNTSKASPPITHHSIVNGQSSVLSARRDSSSHEETGASHTLYGHGVCKWPGCESICEDF 360
361 GQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSP 420
421 KPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHS 480
481 DKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAY 540
541 FRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPT 600
601 SLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSP 660
661 GCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE
Interface Residues: 495, 497, 544, 547, 549, 550, 551, 553, 554, 555, 557, 558, 567, 569
3D-footprint Homologues: 7yz7_A, 3l2c_A, 7vox_H, 2hdc_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 6el8_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 3qrf_G
Binding Motifs: MA0593.1 awGTAAACAra
FOXP2_HUMAN.H10MO.A|M01166 yTGTTTAcw
MA0593.2 wGTAAACAr
Binding Sites: MA0593.1.1
MA0593.1.10
MA0593.1.11
MA0593.1.12
MA0593.1.13
MA0593.1.14
MA0593.1.15
MA0593.1.16
MA0593.1.17
MA0593.1.18
MA0593.1.19
MA0593.1.2
MA0593.1.20
MA0593.1.3
MA0593.1.4
MA0593.1.5
MA0593.1.6
MA0593.1.7
MA0593.1.8
MA0593.1.9
MA0593.2.1
MA0593.2.10
MA0593.2.11
MA0593.2.12
MA0593.2.13
MA0593.2.14
MA0593.2.15
MA0593.2.16
MA0593.2.17
MA0593.2.18
MA0593.2.19
MA0593.2.2
MA0593.2.20
MA0593.2.3
MA0593.2.4
MA0593.2.5
MA0593.2.6
MA0593.2.7
MA0593.2.8
MA0593.2.9
Publications: Nelson C.S, Fuller C.K, Fordyce P.M, Greninger A.L, Li H, DeRisi J.L. Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets. Nucleic acids research 41:5991-6004 (2013). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.