Transcription Factor
| Accessions: | FOXH1_HUMAN (HOCOMOCO 10), O75593 (JASPAR 2024) |
| Names: | Fast-1, Fast-2, Forkhead activin signal transducer 1, Forkhead activin signal transducer 2, Forkhead box protein H1, FOXH1_HUMAN, hFAST-1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 365 |
| Pfam Domains: | 33-114 Fork head domain |
| Sequence: (in bold interface residues) | 1 MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQII 60 61 RQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEAL 120 121 RLQNTALCRRWQNGGARGAFAKDLGPYVLHGRPYRPPSPPPPPSEGFSIKSLLGGSGEGA 180 181 PWPGLAPQSSPVPAGTGNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGP 240 241 STLSPEPRAWPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSC 300 301 PQCPSTSPAYWGVAPETRGPPGLLCDLDALFQGVPPNKSIYDVWVSHPRDLAAPGPGWLL 360 361 SWCSL |
| Interface Residues: | 26, 28, 30, 76, 78, 79, 80, 82, 83, 84, 86, 87, 96, 104 |
| 3D-footprint Homologues: | 7yz7_A, 7yzb_A, 7yzg_A, 7vox_H, 2hdc_A, 6el8_A, 7tdx_A, 3l2c_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7tdw_A, 3g73_A, 3qrf_G |
| Binding Motifs: | MA0479.1 ybsAATMCACA FOXH1_HUMAN.H10MO.A|M01154 TGTGKATTsgr MA0479.2 AATMCACA |
| Binding Sites: | MA0479.2.4 MA0479.2.6 MA0479.2.11 MA0479.1.1 MA0479.1.10 MA0479.1.11 MA0479.1.12 MA0479.1.13 MA0479.1.14 MA0479.1.15 MA0479.1.16 MA0479.1.17 MA0479.1.18 MA0479.1.19 MA0479.1.2 MA0479.1.20 MA0479.1.3 MA0479.1.4 MA0479.1.5 MA0479.1.6 MA0479.1.7 MA0479.1.8 MA0479.1.9 MA0479.2.1 MA0479.2.10 MA0479.2.12 MA0479.2.13 MA0479.2.14 MA0479.2.15 MA0479.2.16 MA0479.2.17 MA0479.2.18 MA0479.2.19 MA0479.2.2 MA0479.2.20 MA0479.2.3 MA0479.2.5 MA0479.2.7 MA0479.2.8 MA0479.2.9 |
| Publications: | Zhou S, Zawel L, Lengauer C, Kinzler K.W, Vogelstein B. Characterization of human FAST-1, a TGF beta and activin signal transducer. Molecular cell 2:121-7 (1998). [Pubmed] |
| Related annotations: | PaperBLAST |
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