Transcription Factor

Accessions: NFIA_HUMAN (HOCOMOCO 10), Q12857 (JASPAR 2024)
Names: CCAAT-box-binding transcription factor, CTF, NF-I/A, NF1-A, NFI-A, NFIA_HUMAN, Nuclear factor 1 A-type, Nuclear factor 1/A, Nuclear factor I/A, TGGCA-binding protein
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 509
Pfam Domains: 4-46 Nuclear factor I protein pre-N-terminus
69-170 MH1 domain
214-509 CTF/NF-I family transcription modulation region
Sequence:
(in bold interface residues)
1 MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDEL 60
61 LSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCL 120
121 RQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLA 180
181 YFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGT 240
241 GPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRS 300
301 PGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRAS 360
361 PHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPN 420
421 GSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPTYSTPST 480
481 SPANRFVSVGPRDPSFVNIPQQTQSWYLG
Interface Residues: 39, 42, 43, 47
3D-footprint Homologues: 2lkx_A
Binding Motifs: MA0670.1 ggTGCCAArw
NFIA_HUMAN.H10MO.C|M01362 tTGGCacrgwGCCAr
MA0670.2 TGCCAA
Publications: Leahy P, Crawford DR, Grossman G, Gronostajski RM, Hanson RW. CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription. J Biol Chem 274:8813-22 (1999). [Pubmed]
Related annotations: PaperBLAST

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