Transcription Factor
Accessions: | NFIA_HUMAN (HOCOMOCO 10), Q12857 (JASPAR 2024) |
Names: | CCAAT-box-binding transcription factor, CTF, NF-I/A, NF1-A, NFI-A, NFIA_HUMAN, Nuclear factor 1 A-type, Nuclear factor 1/A, Nuclear factor I/A, TGGCA-binding protein |
Organisms: | Homo sapiens |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Length: | 509 |
Pfam Domains: | 4-46 Nuclear factor I protein pre-N-terminus 69-170 MH1 domain 214-509 CTF/NF-I family transcription modulation region |
Sequence: (in bold interface residues) | 1 MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDEL 60 61 LSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCL 120 121 RQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLA 180 181 YFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGT 240 241 GPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRS 300 301 PGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRAS 360 361 PHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPN 420 421 GSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPTYSTPST 480 481 SPANRFVSVGPRDPSFVNIPQQTQSWYLG |
Interface Residues: | 39, 42, 43, 47 |
3D-footprint Homologues: | 2lkx_A |
Binding Motifs: | MA0670.1 ggTGCCAArw NFIA_HUMAN.H10MO.C|M01362 tTGGCacrgwGCCAr MA0670.2 TGCCAA |
Publications: | Leahy P, Crawford DR, Grossman G, Gronostajski RM, Hanson RW. CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription. J Biol Chem 274:8813-22 (1999). [Pubmed] |
Related annotations: | PaperBLAST |
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