Transcription Factor

						

			
Accessions: T044598_1.02 (CISBP 1.02), ZBTB18 (humanC2H2ZF-ChIP Feb2015), Q99592 (JASPAR 2024)

			
Names: T044598_1.02;, ZNF238, ENSG00000179456, Q99592, ZBTB18, 58 kDa repressor protein, TAZ-1, Transcriptional repressor RP58, Translin-associated zinc finger protein 1, ZBT18_HUMAN, Zinc finger and BTB domain-containing protein 18, Zinc finger protein 238, Zinc finger protein C2H2-171
Organisms: Homo sapiens
Libraries: CISBP 1.02 1, humanC2H2ZF-ChIP Feb2015 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]

2 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed]

3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: family:C2H2 ZF, TF family: C2H2;BTB experiment: ChIP-seq/MEME/B1H-RC
Length: 522
Pfam Domains:    14-120 BTB/POZ domain
  370-392 Zinc finger, C2H2 type
  371-392 C2H2-type zinc finger
  411-432 Zinc finger, C2H2 type
  412-432 C2H2-type zinc finger
  425-447 Zinc-finger double domain
  438-460 C2H2-type zinc finger
  438-460 Zinc finger, C2H2 type
  452-476 Zinc-finger double domain
  466-489 C2H2-type zinc finger
  466-489 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR   60
  61 DIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK  120
 121 ATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEP  180
 181 GNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVL  240
 241 DLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKES  300
 301 VSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVS  360
 361 NILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFS  420
 421 CMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGD  480
 481 LYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK
Interface Residues: 380, 381, 382, 383, 384, 387, 388, 390, 391, 393, 394, 397, 400, 420, 421, 422, 423, 424, 426, 427, 428, 430, 433, 435, 448, 449, 450, 451, 452, 453, 454, 455, 456, 459, 476, 477, 478, 479, 480, 481, 482, 483, 487, 488, 499, 500, 501, 502, 505
3D-footprint Homologues: 7n5w_A, 7w1m_H, 5v3j_F, 2i13_A, 5yel_A, 5ei9_F, 1g2f_F, 2gli_A, 5k5l_F, 7eyi_G, 6e94_A, 7ysf_A, 6wmi_A, 1ubd_C, 2jpa_A, 7y3l_A, 1tf3_A, 6jnm_A, 8cuc_F, 8ssu_A, 6ml4_A, 4x9j_A, 8gn3_A, 1mey_C, 6blw_A, 5kkq_D, 6u9q_A, 5kl3_A, 5k5i_A, 2kmk_A, 8ssq_A, 1tf6_A, 5und_A, 8h9h_G, 4m9v_C, 2lt7_A, 7y3m_I, 6a57_A, 1yuj_A, 3uk3_C, 2wbs_A, 1f2i_J, 7txc_E, 2drp_D, 5yj3_D, 1llm_D
Binding Motifs: MA0698.1 hatCCAGATGTkb
M3841_1.02 kCCAGATGTKym
ZBTB18_ChIP GCAGCTGCK
MA0698.2 atCCAGATGTk
			
Publications: Aoki K., Meng G., Suzuki K., Takashi T., Kameoka Y., Nakahara K., Ishida R., Kasai M. RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression.. J. Biol. Chem. 273:26698-26704 (1998). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.