Transcription Factor

Accessions: Q07120 (JASPAR 2024)
Names: GFI1_RAT, Growth factor independent protein 1, Zinc finger protein Gfi-1
Organisms: Rattus norvegicus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 423
Pfam Domains: 256-279 Zinc finger, C2H2 type
256-279 C2H2-type zinc finger
271-296 Zinc-finger double domain
285-307 Zinc finger, C2H2 type
285-307 C2H2-type zinc finger
286-309 C2H2-type zinc finger
299-324 Zinc-finger double domain
313-335 Zinc finger, C2H2 type
313-332 Zinc-finger of C2H2 type
313-335 C2H2-type zinc finger
315-331 C2H2-type zinc finger
328-351 Zinc-finger double domain
341-359 C2H2-type zinc finger
341-363 Zinc finger, C2H2 type
341-350 C2H2-type zinc finger
356-379 Zinc-finger double domain
368-391 C2H2-type zinc finger
369-391 C2H2-type zinc finger
369-391 Zinc finger, C2H2 type
383-406 Zinc-finger double domain
397-420 C2H2-type zinc finger
398-420 Zinc finger, C2H2 type
399-420 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 MPRSFLVKSKKAHSYHQPRSPGPDYSLRLETVPVPGRADGGAVSAGESKMEPRERLSPES 60
61 QLTEAPDRASASPNSCEGSVCDPSSEFEDYWRPPSPSVSPASEKSLCRSLDEAQPYTLPF 120
121 KPYAWSGLAGSDLRHLVQSYRQCSALERSAGLSLFCERGAESGRPAARYGSEQAAGGAGA 180
181 GQPGSCGAASGATSAGGLGLYGDFAPAAAGLFERPSTAAGRLYQDRGHELHADKSVGVKV 240
241 ESELLCTRLLLGGGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSL 300
301 EQHKAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHT 360
361 FIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQH 420
421 GLK
Interface Residues: 214, 216, 217, 220, 242, 243, 244, 267, 269, 270, 273, 277, 295, 296, 297, 298, 299, 302, 303, 306, 313, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 336, 351, 352, 353, 354, 355, 357, 358, 361, 379, 380, 381, 382, 383, 385, 386, 407, 408, 409, 410, 411, 412, 413, 414, 418
3D-footprint Homologues: 5v3j_F, 6wmi_A, 5und_A, 8ssq_A, 1tf6_A, 5kkq_D, 8ssu_A, 8gh6_A, 7y3m_I, 6jnm_A, 5k5i_A, 7w1m_H, 4m9v_C, 6e94_A, 7ysf_A, 2i13_A, 5yel_A, 2kmk_A, 7n5w_A, 5ei9_F, 8gn3_A, 2drp_D, 2gli_A, 6ml4_A, 8h9h_G, 7eyi_G, 2lt7_A, 6a57_A, 2jpa_A, 1ubd_C, 3uk3_C, 1tf3_A, 1mey_C, 7txc_E, 5kl3_A, 1f2i_J, 1g2f_F, 5k5l_F, 4x9j_A, 6blw_A, 2wbs_A, 6u9q_A, 8cuc_F, 7y3l_A, 1llm_D, 5yj3_D
Binding Motifs: MA0038.1 ymAATCacwg
Binding Sites: MA0038.1.1
MA0038.1.10
MA0038.1.11
MA0038.1.12
MA0038.1.13
MA0038.1.14
MA0038.1.15
MA0038.1.16
MA0038.1.17
MA0038.1.18
MA0038.1.19
MA0038.1.2
MA0038.1.20
MA0038.1.3
MA0038.1.4
MA0038.1.5
MA0038.1.6
MA0038.1.7
MA0038.1.8
MA0038.1.9
Publications: Zweidler-McKay P. A., Grimes H. L., Flubacher M. M., Tsichlis P. N. Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor. Mol. Cell. Biol. 16:4024-4034 (1996). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.