Transcription Factor

Accessions: HNF4G_HUMAN (HOCOMOCO 10), Q14541 (JASPAR 2024)
Names: Hepatocyte nuclear factor 4-gamma, HNF-4-gamma, HNF4G_HUMAN, Nuclear receptor subfamily 2 group A member 2
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q14541
Length: 408
Pfam Domains: 11-79 Zinc finger, C4 type (two domains)
123-312 Ligand-binding domain of nuclear hormone receptor
Sequence:
(in bold interface residues)
1 MNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDK 60
61 RNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVS 120
121 SPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 180
181 LLGATKRSMMYKDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACL 240
241 KAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITW 300
301 QMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMS 360
361 TLVHADQISTPETPLPSPPQGSGQEQYKIAANQASVISHQHLSKQKQL
Interface Residues: 20, 21, 23, 24, 30, 31, 33, 34, 37, 38, 62, 84, 86, 88, 91, 93, 100
3D-footprint Homologues: 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A
Binding Motifs: MA0484.1 arrGkyCAAAGkyCA
HNF4G_HUMAN.H10MO.C|M01226 rrGkyCAAAGkyCA
MA0484.2 kyCAAAGTCCArr
MA0484.3 CAAAGTCCA
Binding Sites: MA0484.1.1
MA0484.1.10
MA0484.1.11
MA0484.1.12
MA0484.1.13
MA0484.1.14
MA0484.1.15
MA0484.1.16
MA0484.1.17
MA0484.1.18
MA0484.1.19
MA0484.1.2
MA0484.1.20
MA0484.1.3
MA0484.1.4
MA0484.1.5
MA0484.1.6
MA0484.1.7
MA0484.1.8
MA0484.1.9
MA0484.2.8
MA0484.2.5 / MA0484.2.9
MA0484.2.12 / MA0484.2.7
MA0484.2.1
MA0484.2.2
MA0484.2.4
MA0484.2.3 / MA0484.2.5
MA0484.2.4 / MA0484.2.6
MA0484.2.7
MA0484.2.10 / MA0484.2.6
MA0484.2.11
MA0484.2.13
MA0484.2.14 / MA0484.2.8
MA0484.2.15 / MA0484.2.9
MA0484.2.10 / MA0484.2.16
MA0484.2.11 / MA0484.2.17
MA0484.2.12 / MA0484.2.18
MA0484.2.13 / MA0484.2.19
MA0484.2.20
MA0484.2.3
MA0484.2.14
MA0484.2.15
MA0484.2.16
MA0484.2.17
MA0484.2.18
MA0484.2.19
MA0484.2.20
MA0484.3.6
MA0484.3.1 / MA0484.3.13 / MA0484.3.14 / MA0484.3.15 / MA0484.3.7
MA0484.3.8
MA0484.3.9
MA0484.3.10
MA0484.3.2
MA0484.3.3
MA0484.3.12 / MA0484.3.4
MA0484.3.5
MA0484.3.11
MA0484.3.16
MA0484.3.17
MA0484.3.18
MA0484.3.19
MA0484.3.20
Publications: Fang B, Mane-Padros D, Bolotin E, Jiang T, Sladek F.M. Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors. Nucleic acids research 40:5343-56 (2012). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.