Transcription Factor
Accessions: | HNF4G_HUMAN (HOCOMOCO 10), Q14541 (JASPAR 2024) |
Names: | Hepatocyte nuclear factor 4-gamma, HNF-4-gamma, HNF4G_HUMAN, Nuclear receptor subfamily 2 group A member 2 |
Organisms: | Homo sapiens |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | Q14541 |
Length: | 408 |
Pfam Domains: | 11-79 Zinc finger, C4 type (two domains) 123-312 Ligand-binding domain of nuclear hormone receptor |
Sequence: (in bold interface residues) | 1 MNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDK 60 61 RNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVS 120 121 SPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 180 181 LLGATKRSMMYKDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACL 240 241 KAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITW 300 301 QMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMS 360 361 TLVHADQISTPETPLPSPPQGSGQEQYKIAANQASVISHQHLSKQKQL |
Interface Residues: | 20, 21, 23, 24, 30, 31, 33, 34, 37, 38, 62, 84, 86, 88, 91, 93, 100 |
3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A |
Binding Motifs: | MA0484.1 arrGkyCAAAGkyCA HNF4G_HUMAN.H10MO.C|M01226 rrGkyCAAAGkyCA MA0484.2 kyCAAAGTCCArr MA0484.3 CAAAGTCCA |
Binding Sites: | MA0484.1.1 MA0484.1.10 MA0484.1.11 MA0484.1.12 MA0484.1.13 MA0484.1.14 MA0484.1.15 MA0484.1.16 MA0484.1.17 MA0484.1.18 MA0484.1.19 MA0484.1.2 MA0484.1.20 MA0484.1.3 MA0484.1.4 MA0484.1.5 MA0484.1.6 MA0484.1.7 MA0484.1.8 MA0484.1.9 MA0484.2.8 MA0484.2.5 / MA0484.2.9 MA0484.2.12 / MA0484.2.7 MA0484.2.1 MA0484.2.2 MA0484.2.4 MA0484.2.3 / MA0484.2.5 MA0484.2.4 / MA0484.2.6 MA0484.2.7 MA0484.2.10 / MA0484.2.6 MA0484.2.11 MA0484.2.13 MA0484.2.14 / MA0484.2.8 MA0484.2.15 / MA0484.2.9 MA0484.2.10 / MA0484.2.16 MA0484.2.11 / MA0484.2.17 MA0484.2.12 / MA0484.2.18 MA0484.2.13 / MA0484.2.19 MA0484.2.20 MA0484.2.3 MA0484.2.14 MA0484.2.15 MA0484.2.16 MA0484.2.17 MA0484.2.18 MA0484.2.19 MA0484.2.20 MA0484.3.6 MA0484.3.1 / MA0484.3.13 / MA0484.3.14 / MA0484.3.15 / MA0484.3.7 MA0484.3.8 MA0484.3.9 MA0484.3.10 MA0484.3.2 MA0484.3.3 MA0484.3.12 / MA0484.3.4 MA0484.3.5 MA0484.3.11 MA0484.3.16 MA0484.3.17 MA0484.3.18 MA0484.3.19 MA0484.3.20 |
Publications: | Fang B, Mane-Padros D, Bolotin E, Jiang T, Sladek F.M. Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors. Nucleic acids research 40:5343-56 (2012). [Pubmed] |
Related annotations: | PaperBLAST |
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