Transcription Factor
| Accessions: | CUX2_DBD (HumanTF 1.0), CUX2 (HT-SELEX2 May2017) |
| Names: | CUX2, CUX2_HUMAN, Homeobox protein cut-like 2, Homeobox protein cux-2, ENSG00000111249 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | O14529 |
| Notes: | Ensembl ID: ENSG00000111249; DNA-binding domain sequence; TF family: homeodomain+cut; Clone source: Gene synthesis, TF family: CUT_Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: CUT_Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 799 |
| Pfam Domains: | 26-102 CUT domain 365-440 CUT domain 518-597 CUT domain 645-701 Homeobox domain 666-698 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 PGPEPLGGPEPADGGGGGAAGPGAEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLS 60 61 QGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQRGSITPRIRTPE 120 121 TGSDDAIKSILEQAKKEIESQKGGEPKTSVAPLSIANGTTPASTSEDAIKSILEQARREM 180 181 QAQQQALLEMEVAPRGRSVPPSPPERPSLATASQNGAPALVKQEEGSGGPAQAPLPVLSP 240 241 AAFVQSIIRKVKSEIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSSSGYSGQPNGRAW 300 301 PRGDEAPVPPEDEAAAGAEDEPPRTGELKAEGATAEAGARLPYYPAYVPRTLKPTVPPLT 360 361 PEQYELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKL 420 421 TQKGREPFIRMQLWLSDQLGQAVGQQPGASQASPTEPRSSPSPPPSPTEPEKSSQEPLSL 480 481 SLESSKENQQPEGRSSSSLSGKMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNN 540 541 LGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHNVEKLRDMKK 600 601 LEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALR 660 661 KAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGP 720 721 GILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQVRIKQEQME 780 781 EDAEEEAGSQPQDSGELDK |
| Interface Residues: | 60, 61, 63, 65, 66, 403, 404, 406, 408, 409, 645, 646, 648, 689, 690, 693, 694, 697, 698, 701 |
| 3D-footprint Homologues: | 2o4a_A, 2d5v_B, 3cmy_A, 1fjl_B, 5zfz_A, 3d1n_M, 2lkx_A, 1au7_A, 3l1p_A, 4xrs_G, 3lnq_A, 5hod_A, 1jgg_B, 1e3o_C, 6fqp_B, 1o4x_A, 6fqq_E, 1puf_B, 8g87_X, 4qtr_D, 4xrm_B |
| Binding Motifs: | CUX2_DBD_1 ATCrATAawwwtATCGAT CUX2_DBD_2 TrATCRATaa CUX2_2 cTgATCGATyrg CUX2_methyl_1 cyrATCGATyrg |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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