Transcription Factor
| Accessions: | PDX1_MOUSE (HOCOMOCO 10), NP_032840 (JASPAR 2024), P52946 (JASPAR 2024) |
| Names: | IDX-1, Insulin promoter factor 1, IPF-1, Islet/duodenum homeobox 1, Pancreas/duodenum homeobox protein 1, PDX1_MOUSE, Somatostatin-transactivating factor 1, STF-1 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 284 |
| Pfam Domains: | 148-204 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MNSEEQYYAATQLYKDPCAFQRGPVPEFSANPPACLYMGRQPPPPPPPQFTSSLGSLEQG 60 61 SPPDISPYEVPPLASDDPAGAHLHHHLPAQLGLAHPPPGPFPNGTEPGGLEEPNRVQLPF 120 121 PWMKSTKAHAWKGQWAGGAYTAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVEL 180 181 AVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTPSGGGGGEEPEQDCAVTSGEELLAVP 240 241 PLPPPGGAVPPGVPAAVREGLLPSGLSVSPQPSSIAPLRPQEPR |
| Interface Residues: | 118, 124, 125, 128, 148, 149, 150, 151, 189, 190, 192, 193, 196, 197, 200, 201, 204 |
| 3D-footprint Homologues: | 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 3cmy_A, 1fjl_B, 3d1n_M, 6a8r_A, 1zq3_P, 3lnq_A, 1jgg_B, 2lkx_A, 1nk2_P, 7q3o_C, 2ld5_A, 6es3_K, 5jlw_D, 4xrs_G, 3a01_E, 3rkq_B, 6m3d_C, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 1puf_B, 7psx_B, 5hod_A, 2hos_A, 1b72_A, 2xsd_C, 7xrc_C, 1e3o_C, 1le8_A, 1au7_A, 1o4x_A, 1du0_A, 4qtr_D |
| Binding Motifs: | PDX1_MOUSE.H10MO.C|M01286 rSTmATTAG MA0132.1 cTAATk PH0081.1 marsTAATTAgywcAt |
| Binding Sites: | MA0132.1.1 / MA0132.1.2 MA0132.1.10 MA0132.1.11 MA0132.1.12 MA0132.1.13 MA0132.1.14 MA0132.1.15 MA0132.1.16 MA0132.1.17 MA0132.1.18 MA0132.1.19 MA0132.1.20 MA0132.1.3 MA0132.1.4 MA0132.1.5 MA0132.1.6 MA0132.1.7 MA0132.1.8 MA0132.1.9 |
| Publications: | Liberzon A, Ridner G, Walker M.D. Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1. Nucleic acids research 32:54-64 (2004). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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