Transcription Factor
| Accessions: | NFIX (HT-SELEX2 May2017), Q14938 (JASPAR 2024) |
| Names: | ENSG00000008441, NFIX, CCAAT-box-binding transcription factor, CTF, NF-I/X, NF1-X, NFI-X, NFIX_HUMAN, Nuclear factor 1 X-type, Nuclear factor 1/X, Nuclear factor I/X, TGGCA-binding protein |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q14938 |
| Notes: | TF family: NFI experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: NFI experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 502 |
| Pfam Domains: | 4-46 Nuclear factor I protein pre-N-terminus 69-169 MH1 domain 213-502 CTF/NF-I family transcription modulation region |
| Sequence: (in bold interface residues) | 1 MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDEL 60 61 LGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCL 120 121 RQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLA 180 181 YFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASG 240 241 PNFSLADLESPSYYNINQVTLGRRSITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGR 300 301 SPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPG 360 361 SPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQPN 420 421 GSGQGKVPGSFLLPPPPPVARPVPLPMPDSKSTSTAPDGAALTPPSPSFATTGASSANRF 480 481 VSIGPRDGNFLNIPQQSQSWFL |
| Interface Residues: | 39, 42, 43, 47, 379, 426 |
| 3D-footprint Homologues: | 2lkx_A, 6n7w_H |
| Binding Motifs: | MA0671.1 sgtGCCArv MA1528.1 / NFIX_2 gtTGGCrysgTGCCArs NFIX_methyl_1 stTGGCrysgTGCCArs MA0671.2 tGCCAr MA1528.2 tTGGCrysgTGCCA |
| Publications: | Messina G, Biressi S, Monteverde S, Magli A, Cassano M, Perani L, Roncaglia E, Tagliafico E, Starnes L, Campbell CE, Grossi M, Goldhamer DJ, Gronostajski RM, Cossu G. Nfix regulates fetal-specific transcription in developing skeletal muscle. Cell 140:554-66 (2010). [Pubmed] Heng YH, Barry G, Richards LJ, Piper M. Nuclear factor I genes regulate neuronal migration. Neurosignals : (2012;20(3):159-67.). [Pubmed] |
| Related annotations: | PaperBLAST |
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