Transcription Factor
| Accessions: | Q8BG99 (JASPAR 2024) |
| Names: | Homeobox protein PKNOX2, Homeobox protein PREP-2, PBX/knotted homeobox 2, PKNX2_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 474 |
| Pfam Domains: | 298-345 Homeobox domain 306-345 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSATASTPVPSAP 60 61 IDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEH 120 121 KPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDL 180 181 GGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSG 240 241 GALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHAT 300 301 NIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAP 360 361 KAKKIKSQHRPTQRFWPNSIAAGVLQQQGGTPGTNPDGSINLDNLQSLSSDNATMAMQQA 420 421 MMAAHDDSLDGTEEEDEDDMEEEEEEEEELEEEADELQTTNVSDLGLEHSDSLE |
| Interface Residues: | 289, 291, 292, 294, 333, 334, 336, 337, 340, 341, 342, 344, 345 |
| 3D-footprint Homologues: | 6fqp_B, 1puf_A, 1puf_B, 4j19_B, 1mnm_C, 2ld5_A, 1le8_A, 2lkx_A, 1le8_B, 6fqq_E, 2d5v_B, 1fjl_B, 4xrm_B, 7psx_B, 1k61_B, 4xrs_G |
| Binding Motifs: | PH0141.1 aarsrsCTGTCAathy |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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