Transcription Factor

						

			
Accessions: 5yel_A (3D-footprint 20231221)

			
Names: 11-zinc finger protein, CCCTC-binding factor, CTCF_HUMAN, CTCFL paralog, Transcriptional repressor CTCF
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P49711
Length: 166
Pfam Domains:      1-14 C2H2-type zinc finger
     2-25 C2H2-type zinc finger
    29-53 C2H2-type zinc finger
    29-52 Zinc finger, C2H2 type
    29-52 C2H2-type zinc finger
    60-82 C2H2-type zinc finger
    60-81 Zinc finger, C2H2 type
    60-81 C2H2-type zinc finger
    74-95 Zinc-finger double domain
  104-124 Zinc-finger double domain
  114-137 C2H2-type zinc finger
  114-124 C2H2-type zinc finger
  114-137 Zinc finger, C2H2 type
  116-160 LIM domain
  129-155 Zinc-finger double domain
  144-165 Zinc finger, C2H2 type
  144-165 C2H2-type zinc finger
  144-155 C2H2-type zinc finger
Sequence: 
(in bold interface residues)		   1 PYECYICHARFTQSGTMKMHILQKHVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKK   60
  61 CRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYASRQERHMIMHKRTHTGKPYACSHCD  120
 121 KTFRQKQLLDMHFKRYHDPVPAAFVCSKCGKTFTRRNTMARHADNC
Interface Residues: 13, 14, 15, 16, 18, 19, 29, 40, 41, 42, 43, 46, 49, 51, 69, 70, 71, 72, 73, 75, 76, 78, 79, 82, 96, 97, 98, 99, 100, 101, 103, 104, 105, 108, 124, 125, 126, 127, 128, 129, 130, 131, 132, 135, 154, 155, 156, 157, 158, 161
3D-footprint Homologues: 5k5i_A, 8ssq_A, 7w1m_H, 5und_A, 8ssu_A, 5v3j_F, 2i13_A, 5kkq_D, 1yuj_A, 2drp_D, 6e94_A, 5yel_A, 2kmk_A, 5k5l_F, 6blw_A, 7ysf_A, 1ubd_C, 6jnm_A, 7n5w_A, 1tf3_A, 3uk3_C, 6wmi_A, 6ml4_A, 4x9j_A, 1f2i_J, 6u9q_A, 5ei9_F, 7eyi_G, 8h9h_G, 1tf6_A, 6a57_A, 2lt7_A, 2jpa_A, 8cuc_F, 7y3l_A, 1g2f_F, 8gn3_A, 1mey_C, 2wbs_A, 7txc_E, 4m9v_C, 7y3m_I, 5kl3_A, 2gli_A, 1llm_D, 5yj3_D
Binding Motifs: 5yel_A ACTGgnnnnnnnnGGTACnGCA
Binding Sites: 5yel_E
5yel_F
			
Publications: Yin M, Wang J, Wang M, Li X, Zhang M, Wu Q, Wang Y. Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites. Cell Res 27:1365-1377 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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