Transcription Factor

Accessions: IRF9_MOUSE (HOCOMOCO 10), Q61179 (JASPAR 2024)
Names: IFN-alpha-responsive transcription factor subunit, Interferon regulatory factor 9, Interferon-stimulated gene factor 3 gamma, IRF-9, IRF9_MOUSE, ISGF-3 gamma, ISGF3 p48 subunit, Transcriptional regulator ISGF3 subunit gamma
Organisms: Mus musculus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 399
Pfam Domains: 11-116 Interferon regulatory factor transcription factor
212-375 Interferon-regulatory factor 3
Sequence:
(in bold interface residues)
1 MASGKVRCTRKLRSWIVEQVESGHFPGVCWDDAAKTMFRIPWKHAGKQDFREDQDAAIFK 60
61 AWALFKEKHKDGDIGHPAVWKTRLRCALNKSSEFEEVPERGRMDVAEPYKVYRILPAGTL 120
121 PNQPRNQKSPCKRSISCVSPEREENMENGRTNGVVNHSDSGSNIGGGGNGSNRSDSNSNC 180
181 NSELEEGAGTTEATIREDPVFLEHQLPLNSDYSLLLTFIYGGRVVGKTQVHSLDCRLVAE 240
241 RSDSESSMEQVEFPKPDPLEPTQHLLNQLDRGVLVASNSRGLFVQRLCPIPISWNAPEAP 300
301 PGPGPHLLPSNKCVELFKTTYFCRDLAQYFQGQGPPPKFQATLHFWEESPGSSHSQENLI 360
361 TVQMEQAFARHLLEKIPEEEKAALFLLQHTEQSPSALGH
Interface Residues: 44, 46, 78, 82, 83, 85, 86, 89, 90
3D-footprint Homologues: 2pi0_B, 1if1_B, 2irf_L, 7oot_B, 2o61_A
Binding Motifs: PB0037.1 mrrAAwCGAAACyaA
PB0141.1 gsaaAAcabkactr
IRF9_MOUSE.H10MO.C|M01178 GAAAgcGAAAyT
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

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