Transcription Factor

Accessions: T061540_1.02 (CISBP 1.02), P39943 (JASPAR 2024)
Names: MIG3, T061540_1.02;, MIG3_YEAST, Multicopy inhibitor of growth protein 3, Transcription corepressor MIG3
Organisms: Saccharomyces cerevisiae
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:C2H2 ZF
Length: 394
Pfam Domains: 33-58 Zinc-finger double domain
45-69 Zinc finger, C2H2 type
45-69 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 MNYLRDRFPPDNDQRPFRCEICSRGFHRLEHKKRHGRTHTGEKPHKCTVQGCPKSFSRSD 60
61 ELKRHLRTHTKGVQRRRIKSKGSRKTVVNTATAAPTTFNENTGVSLTGIGQSKVPPILIS 120
121 VAQNCDDVNIRNTGNNNGIVETQAPAILVPVINIPNDPHPIPSSLSTTSITSIASVYPST 180
181 SPFQYLKSGFPEDPASTPYVHSSGSSLALGELSSNSSIFSKSRRNLAAMSGPDSLSSSKN 240
241 QSSASLLSQTSHPSKSFSRPPTDLSPLRRIMPSVNTGDMEISRTVSVSSSSSSLTSVTYD 300
301 DTAAKDMGMGIFFDRPPVTQKACRSNHKYKVNAVSRGRQHERAQFHISGDDEDSNVHRQE 360
361 SRASNTSPNVSLPPIKSILRQIDNFNSAPSYFSK
Interface Residues: 3, 5, 6, 25, 26, 27, 28, 29, 30, 31, 33, 34, 35, 36, 37, 40, 57, 58, 59, 60, 61, 62, 63, 64, 65, 68, 84, 85, 86, 87, 90, 91, 92, 257, 259, 268
3D-footprint Homologues: 6wmi_A, 2lt7_A, 6ml4_A, 5und_A, 5kkq_D, 8ssu_A, 6jnm_A, 3uk3_C, 2kmk_A, 8ssq_A, 7w1m_H, 8cuc_F, 1g2f_F, 7y3l_A, 5ei9_F, 8h9h_G, 1mey_C, 2drp_D, 7ysf_A, 1f2i_J, 7eyi_G, 6a57_A, 5k5i_A, 5v3j_F, 7n5w_A, 6blw_A, 6u9q_A, 5yel_A, 4x9j_A, 2i13_A, 8gn3_A, 1llm_D, 7txc_E, 5kl3_A, 1ubd_C, 4m9v_C, 1tf3_A, 1tf6_A, 6e94_A, 7y3m_I, 2jpa_A, 2gli_A, 2wbs_A, 5yj3_D, 7u5d_E
Binding Motifs: M0511_1.02 rTGCGGGGkt
MA0339.1 CCCCrCa
MA0339.2 CCCCrC
Publications: Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed]
Related annotations: PaperBLAST

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