Transcription Factor

						

			
Accessions: CTCF (SMILE-seq 1.0)

			
Names: 11-zinc finger protein, CCCTC-binding factor, CTCF, CTCF_HUMAN, CTCFL paralog, Transcriptional repressor CTCF
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: P49711
Notes: TF family: znfC2H2
Length: 726
Pfam Domains:   266-288 C2H2-type zinc finger
  266-288 Zinc finger, C2H2 type
  280-305 Zinc-finger double domain
  294-316 C2H2-type zinc finger
  294-316 Zinc finger, C2H2 type
  309-333 Zinc-finger double domain
  322-345 C2H2-type zinc finger
  322-345 Zinc finger, C2H2 type
  337-360 Zinc-finger double domain
  366-387 Zinc-finger double domain
  379-401 C2H2-type zinc finger
  379-401 Zinc finger, C2H2 type
  394-417 Zinc-finger double domain
  407-430 C2H2-type zinc finger
  437-460 C2H2-type zinc finger
  437-460 Zinc finger, C2H2 type
  468-489 C2H2-type zinc finger
  482-504 Zinc-finger double domain
  512-533 Zinc-finger double domain
  523-546 C2H2-type zinc finger
  538-566 Zinc-finger double domain
  555-577 C2H2-type zinc finger
  555-576 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MEGDAVEAIVEESETFIKGKERKTYQRRREGGQEEDACHLPQNQTDGGEVVQDVNSSVQM   60
  61 VMMEQLDPTLLQMKTEVMEGTVAPEAEAAVDDTQIITLQVVNMEEQPINIGELQLVQVPV  120
 121 PVTVPVATTSVEELQGAYENEVSKEGLAESEPMICHTLPLPEGFQVVKVGANGEVETLEQ  180
 181 GELPPQEDPSWQKDPDYQPPAKKTKKTKKSKLRYTEEGKDVDVSVYDFEEEQQEGLLSEV  240
 241 NAEKVVGNMKPPKPTKIKKKGVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCG  300
 301 RAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYAS  360
 361 VEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSG  420
 421 TMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERY  480
 481 ALIQHQKSHKNEKRFKCDQCDYACRQERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDM  540
 541 HFKRYHDPNFVPAAFVCSKCGKTFTRRNTMARHADNCAGPDGVEGENGGETKKSKRGRKR  600
 601 KMRSKKEDSSDSENAEPDLDDNEDEEEPAVEIEPEPEPQPVTPAPPPAKKRRGRPPGRTN  660
 661 QPKQNQPTAIIQVEDQNTGAIENIIVEVKKEPDAEPAEGEEEEAQPAATDAPNGDLTPEM  720
 721 ILSMMD
Interface Residues: 266, 276, 277, 278, 279, 280, 283, 304, 305, 306, 307, 308, 311, 332, 333, 334, 335, 336, 338, 339, 341, 342, 343, 346, 362, 363, 364, 365, 367, 368, 369, 386, 388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 417, 418, 419, 420, 421, 423, 424, 425, 428, 447, 448, 449, 450, 451, 454, 457, 477, 478, 480, 481, 484, 490, 504, 505, 506, 507, 508, 509, 512, 516, 533, 534, 535, 536, 537, 538, 540, 544, 565, 566, 568, 569, 572
3D-footprint Homologues: 2kmk_A, 7y3l_A, 1mey_C, 7w1m_H, 2i13_A, 2gli_A, 6wmi_A, 6jnm_A, 6a57_A, 6e94_A, 1ubd_C, 7n5w_A, 5ei9_F, 5yj3_D, 8ssq_A, 8ssu_A, 5kkq_D, 8h9h_G, 7eyi_G, 7ysf_A, 2jpa_A, 6u9q_A, 7txc_E, 5kl3_A, 1f2i_J, 5und_A, 1g2f_F, 6ml4_A, 5v3j_F, 4x9j_A, 6blw_A, 4m9v_C, 2lt7_A, 3uk3_C, 8cuc_F, 2wbs_A, 5k5i_A, 8gn3_A, 1llm_D, 7y3m_I, 2drp_D, 5yel_A, 5k5l_F, 1tf3_A, 1tf6_A
Binding Motifs: CTCF waGGgGGcGstrkwgsg
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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