Transcription Factor
| Accessions: | ELF1_HUMAN (HOCOMOCO 10), P32519 (JASPAR 2024) |
| Names: | E74-like factor 1, ELF1_HUMAN, ETS-related transcription factor Elf-1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P32519 |
| Length: | 619 |
| Pfam Domains: | 1-111 Transcription factor protein N terminal 208-291 Ets-domain |
| Sequence: (in bold interface residues) | 1 MAAVVQQNDLVFEFASNVMEDERQLGDPAIFPAVIVEHVPGADILNSYAGLACVEEPNDM 60 61 ITESSLDVAEEEIIDDDDDDITLTVEASCHDGDETIETIEAAEALLNMDSPGPMLDEKRI 120 121 NNNIFSSPEDDMVVAPVTHVSVTLDGIPEVMETQQVQEKYADSPGASSPEQPKRKKGRKT 180 181 KPPRPDSPATTPNISVKKKNKDGKGNTIYLWEFLLALLQDKATCPKYIKWTQREKGIFKL 240 241 VDSKAVSRLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLIYIN 300 301 DEDPSSSIESSDPSLSSSATSNRNQTSRSRVSSSPGVKGGATTVLKPGNSKAAKPKDPVE 360 361 VAQPSEVLRTVQPTQSPYPTQLFRTVHVVQPVQAVPEGEAARTSTMQDETLNSSVQSIRT 420 421 IQAPTQVPVVVSPRNQQLHTVTLQTVPLTTVIASTDPSAGTGSQKFILQAIPSSQPMTVL 480 481 KENVMLQSQKAGSPPSIVLGPAQVQQVLTSNVQTICNGTVSVASSPSFSATAPVVTFSPR 540 541 SSQLVAHPPGTVITSVIKTQETKTLTQEVEKKESEDHLKENTEKTEQQPQPYVMVVSSSN 600 601 GFTSQVAMKQNELLEPNSF |
| Interface Residues: | 262, 263, 265, 266, 267, 269, 270, 284, 451, 458, 470 |
| 3D-footprint Homologues: | 1dux_F, 4uno_A, 3jtg_A, 3zp5_A, 7jsa_J, 4mhg_A, 2stt_A, 8ee9_F, 4iri_A, 4l18_B, 1awc_A, 4lg0_B, 1yo5_C, 4bqa_A, 1bc8_C, 6fbc_A, 1tau_A |
| Binding Motifs: | MA0473.2 aACCCGGAAGTr MA0473.1 rramCmGGAAGTg ELF1_HUMAN.H10MO.A|M01102 gaacCmGGAAGtgs MA0473.3 aamCAGGAAGTGrv MA0473.4 CAGGAAGTG |
| Binding Sites: | MA0473.1.1 MA0473.1.10 MA0473.1.11 MA0473.1.12 MA0473.1.13 MA0473.1.14 MA0473.1.15 MA0473.1.16 MA0473.1.17 MA0473.1.18 MA0473.1.19 MA0473.1.2 MA0473.1.20 MA0473.1.3 MA0473.1.4 MA0473.1.5 MA0473.1.6 MA0473.1.7 MA0473.1.8 MA0473.1.9 MA0473.3.1 MA0473.3.10 MA0473.3.11 / MA0473.3.9 MA0473.3.10 / MA0473.3.12 MA0473.3.13 MA0473.3.11 / MA0473.3.14 MA0473.3.12 / MA0473.3.15 MA0473.3.13 / MA0473.3.16 MA0473.3.14 / MA0473.3.17 MA0473.3.15 / MA0473.3.18 MA0473.3.16 / MA0473.3.19 MA0473.3.2 MA0473.3.20 MA0473.3.3 MA0473.3.4 MA0473.3.4 / MA0473.3.5 MA0473.3.5 / MA0473.3.6 MA0473.3.6 / MA0473.3.7 MA0473.3.7 / MA0473.3.8 MA0473.3.8 / MA0473.3.9 MA0473.3.19 MA0473.3.1 MA0473.3.17 MA0473.3.18 MA0473.3.20 MA0473.4.1 MA0473.4.10 / MA0473.4.15 / MA0473.4.19 / MA0473.4.3 / MA0473.4.4 / MA0473.4.8 MA0473.4.11 MA0473.4.12 / MA0473.4.20 / MA0473.4.5 / MA0473.4.6 MA0473.4.13 MA0473.4.14 MA0473.4.16 MA0473.4.17 MA0473.4.18 MA0473.4.2 / MA0473.4.9 MA0473.4.7 |
| Publications: | Oettgen P., Akbarali Y., Boltax J., Best J., Kunsch C., Libermann T. A. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. Mol. Cell. Biol. 16:5091-5106 (1996). [Pubmed] Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed] |
| Related annotations: | PaperBLAST |
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