Transcription Factor

Accessions: ERF2 (Athamap 20091028), T000696_1.02 (CISBP 1.02), O80338 (JASPAR 2024), T21847 (AthalianaCistrome v4_May2016)
Names: AtERF2, EREBP-2, ERF2, Ethylene-responsive element-binding factor 2, Ethylene-responsive transcription factor 2, T000696_1.02;, EF101_ARATH, AT5G47220, T21847;
Organisms: Arabidopsis thaliana
Libraries: Athamap 20091028 1, CISBP 1.02 2, JASPAR 2024 3, AthalianaCistrome v4_May2016 4
1 Bulow L, Engelmann S, Schindler M, Hehl R. AthaMap, integrating transcriptional and post-transcriptional data. Nucleic acids research 37:D983-6 (2009). [Pubmed]
2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
4 O'Malley RC, Huang SS, Song L, Lewsey MG, Bartlett A, Nery JR, Galli M, Gallavotti A, Ecker JR. Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape. Cell 165:1280-92 (2016). [Pubmed]
Notes: experiment type:PBM, family:AP2, ecotype:Col-0, experiment type: ampDAP-seq, experiment type: ampDAP-seq (methyl-cytosines removed by PCR), experiment type: DAP-seq, family:AP2-EREBP
Length: 243
Pfam Domains: 116-166 AP2 domain
Sequence:
(in bold interface residues)
1 MYGQCNIESDYALLESITRHLLGGGGENELRLNESTPSSCFTESWGGLPLKENDSEDMLV 60
61 YGLLKDAFHFDTSSSDLSCLFDFPAVKVEPTENFTAMEEKPKKAIPVTETAVKAKHYRGV 120
121 RQRPWGKFAAEIRDPAKNGARVWLGTFETAEDAALAYDIAAFRMRGSRALLNFPLRVNSG 180
181 EPDPVRITSKRSSSSSSSSSSSTSSSENGKLKRRRKAENLTSEVVQVKCEVGDETRVDEL 240
241 LVS
Interface Residues: 121, 123, 124, 125, 129, 131, 133, 136, 141, 143
3D-footprint Homologues: 7wq5_A, 1gcc_A, 5wx9_A, 7et4_D
Binding Motifs: ERF2 AGCCGCCA
M0038_1.02 hsmGCCGcCa
M0109 / MA1262.1 ccdccrccdcCGCCGCCrycr
M0093 cckccgccrcckcCGCCGCCr
MA1262.2 ccdcCGCCGCCry
Binding Sites: ERF2_1
ERF2_2
MA1262.1.6
MA1262.1.7
MA1262.1.5
MA1262.1.10
MA1262.1.1
MA1262.1.11
MA1262.1.12
MA1262.1.13
MA1262.1.14
MA1262.1.15
MA1262.1.16
MA1262.1.17
MA1262.1.18
MA1262.1.19
MA1262.1.2
MA1262.1.20
MA1262.1.3
MA1262.1.4
MA1262.1.8
MA1262.1.9
MA1262.2.1
MA1262.2.10
MA1262.2.11
MA1262.2.12
MA1262.2.13
MA1262.2.14
MA1262.2.15
MA1262.2.16
MA1262.2.17
MA1262.2.18
MA1262.2.19
MA1262.2.2
MA1262.2.20
MA1262.2.3
MA1262.2.4
MA1262.2.5
MA1262.2.6
MA1262.2.7
MA1262.2.8
MA1262.2.9
Publications: Fujimoto SY, Ohta M, Usui A, Shinshi H, Ohme-Takagi M. 2000. Arabidopsis ethylene-responsive element binding factors act as transcriptional activators or repressors of GCC box-mediated gene expression. Plant Cell. 12:393-404. [Pubmed]

Hao D., Ohme-Takagi M., Sarai A. Unique mode of GCC box recognition by the DNA-binding domain of ethylene-responsive element-binding factor (ERF domain) in plant. J. Biol. Chem. 273:26857-26861 (1998). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.