Transcription Factor
| Accessions: | P63013 (JASPAR 2024) |
| Names: | Homeobox protein K-2, Homeobox protein mHox, Paired mesoderm homeobox protein 1, Paired-related homeobox protein 1, PRRX1_MOUSE, PRX-1 |
| Organisms: | Mus musculus, Rattus norvegicus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 245 |
| Pfam Domains: | 95-151 Homeobox domain 219-236 OAR domain |
| Sequence: (in bold interface residues) | 1 MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADESVGEA 60 61 GRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPD 120 121 AFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIV 180 181 PRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQ 240 241 VPTVN |
| Interface Residues: | 35, 37, 38, 81, 94, 95, 96, 97, 98, 136, 137, 139, 140, 143, 144, 147, 148, 151, 155 |
| 3D-footprint Homologues: | 7vwz_G, 5zfz_A, 4j19_B, 6a8r_A, 3cmy_A, 1ig7_A, 3d1n_M, 2h1k_B, 1puf_A, 1fjl_B, 2lkx_A, 1nk2_P, 1zq3_P, 1jgg_B, 6m3d_C, 3lnq_A, 7q3o_C, 6es3_K, 2ld5_A, 1puf_B, 1ic8_B, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 4cyc_A, 1au7_A, 5flv_I, 3l1p_A, 3a01_E, 2h8r_B, 7psx_B, 1b72_A, 5hod_A, 1e3o_C, 2xsd_C, 7xrc_C, 1le8_A, 8g87_X, 4qtr_D, 1du0_A, 1o4x_A, 5zjt_E |
| Binding Motifs: | PH0154.1 vkaayTAATTAryTast |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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